Metachronous primary uterine cancer surgically resected during crizotinib treatment in a ALK-rearranged advanced lung adenocarcinoma

Annamaria Catino, Andrea Misino, Anna Scattone, Lucia Caldarola, Stella Petroni, Antonio Logroscino, Elisabetta Sara Montagna, Gabriella Serio, Giovanni Simone, Domenico Galetta

Research output: Contribution to journalArticle

Abstract

Rearrangements of the anaplastic lymphoma kinase (ALK) gene are present in 3% to 7% of nonsmall-cell lung cancers (NSCLCs). Patients harboring ALK rearrangements show very favourable outcomes if treated with targeted agents, among which crizotinib is the first and best studied. Crizotinib, an oral smallmolecule tyrosine kinase inhibitor of ALK, MET, and ROS1 kinases, is a very active and well tolerated drug. Nevertheless, the optimal therapy management with this new drug is still partially unknown, especially with regard to the safety of combined treatments. Recently, the integration of locoregional treatments has been proposed as a feasible multimodality strategy in selected patients with good clinical conditions and slowgrowing or oligoprogressive disease. In this report, a case of advanced lung adenocarcinoma, progressed after first line chemotherapy and re-biopsied detecting ALK rearrangement, is described. During crizotinib treatment the primary lung tumor showed an excellent regression; meanwhile a major surgery for a metachronous uterine cancer was safely and successfully carried out.

Original languageEnglish
Pages (from-to)145-149
Number of pages5
JournalTranslational Lung Cancer Research
Volume5
Issue number1
DOIs
Publication statusPublished - 2016

Keywords

  • ALK rearrangement
  • Crizotinib therapy
  • Major surgery
  • Metachronous uterine cancer
  • Re-biopsy

ASJC Scopus subject areas

  • Oncology

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