Metadoxine (Metadoxil) in alcoholic liver diseases. Its therapeutic role

G. Annoni, B. Khlat, P. Lampertico, M. Dell'Oca, F. S. Dioguardi

Research output: Contribution to journalArticlepeer-review


The effectiveness and tolerability of metadoxine (Metadoxil) in the treatment of alcoholic liver diseases was investigated by means of a double-blind study by comparison with vitamin B6. Patients treated with metadoxine showed a significant reduction in necrosis and cholestasis indices compared to those untreated. In addition, our studies showed that the mitochondrial GOT serum levels in metadoxine-treated patients were greatly reduced. This is of particular interest since it has recently been shown that the determination of mitrochondrial GOT serum levels is a sensitive and specific laboratory test for detecting ethanol-induced hepatic damage. Our trial has also shown the potential of metadoxine as a valid pharmacological agent in the treatment of alcoholic liver diseases. These results were especially significant when the patients abstained from alcohol consumption during metadoxine therapy.

Original languageEnglish
Pages (from-to)333-341
Number of pages9
JournalClinical Trials Journal
Issue number5
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Pharmacology (medical)


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