The effectiveness and tolerability of metadoxine (Metadoxil) in the treatment of alcoholic liver diseases was investigated by means of a double-blind study by comparison with vitamin B6. Patients treated with metadoxine showed a significant reduction in necrosis and cholestasis indices compared to those untreated. In addition, our studies showed that the mitochondrial GOT serum levels in metadoxine-treated patients were greatly reduced. This is of particular interest since it has recently been shown that the determination of mitrochondrial GOT serum levels is a sensitive and specific laboratory test for detecting ethanol-induced hepatic damage. Our trial has also shown the potential of metadoxine as a valid pharmacological agent in the treatment of alcoholic liver diseases. These results were especially significant when the patients abstained from alcohol consumption during metadoxine therapy.
|Number of pages||9|
|Journal||Clinical Trials Journal|
|Publication status||Published - 1988|
ASJC Scopus subject areas
- Pharmacology (medical)