Abstract
Toxic metals are involved in the pathogenesis of some neurodegenerative and vascular diseases and are known to impair the immune system functions. We report here the case of a patient affected by heavy metal intoxication, who had developed an autoimmune disease. There was evidence of aluminium, cadmium and lead intoxication in a 63-year old Italian woman affected by rheumatoid arthritis (RA). We treated the patient with calcium disodium edetate (EDTA) once a week for a year in order to remove traces of heavy metal intoxication. Oxidative status profile was carried out at the beginning and after 6 months' EDTA chelation. At the end of the treatment, the patient did not show any signs of metal intoxication, RA symptoms and oxidative status improved.
Original language | English |
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Pages (from-to) | 1093-1098 |
Number of pages | 6 |
Journal | BioMetals |
Volume | 24 |
Issue number | 6 |
DOIs | |
Publication status | Published - Dec 2011 |
Keywords
- Chelation therapy
- EDTA
- Metal intoxication
- Rheumathoid arthritis
ASJC Scopus subject areas
- Biomaterials
- Metals and Alloys
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)