Metallo-β-lactamases as emerging resistance determinants in Gram-negative pathogens: open issues

Giuseppe Cornaglia; Murat Akova; Gianfranco Amicosante; Rafael Cantón; Roberto Cauda; Jean Denis Docquier; Mikhail Edelstein; Jean Marie Frère; Miklós Fuzi; Moreno Galleni; Helen Giamarellou; Marek Gniadkowski; Raffaella Koncan; Balázs Libisch; Francesco Luzzaro; Vivi Miriagou; Ferran Navarro; Patrice Nordmann; Laura Pagani; Luisa Peixe; Laurent Poirel; Maria Souli; Evelina Tacconelli; Alkiviadis Vatopoulos; Gian Maria Rossolini

doi:10.1016/j.ijantimicag.2006.10.008

Metallo-β-lactamases as emerging resistance determinants in Gram-negative pathogens: open issues

Giuseppe Cornaglia, Murat Akova, Gianfranco Amicosante, Rafael Cantón, Roberto Cauda, Jean Denis Docquier, Mikhail Edelstein, Jean Marie Frère, Miklós Fuzi, Moreno Galleni, Helen Giamarellou, Marek Gniadkowski, Raffaella Koncan, Balázs Libisch, Francesco Luzzaro, Vivi Miriagou, Ferran Navarro, Patrice Nordmann, Laura Pagani, Luisa PeixeLaurent Poirel, Maria Souli, Evelina Tacconelli, Alkiviadis Vatopoulos, Gian Maria Rossolini

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

The rapid spread of acquired metallo-β-lactamases (MBLs) among major Gram-negative pathogens is a matter of particular concern worldwide and primarily in Europe, one of first continents where the emergence of acquired MBLs has been reported and possibly the geographical area where the increasing diversity of these enzymes and the number of bacterial species affected are most impressive. This spread has not been paralleled by accuracy/standardisation of detection methods, completeness of epidemiological knowledge or a clear understanding of what MBL production entails in terms of clinical impact, hospital infection control and antimicrobial chemotherapy. A number of European experts in the field met to review the current knowledge on this phenomenon, to point out open issues and to reinforce and relate to one another the existing activities set forth by research institutes, scientific societies and European Union-driven networks.

Original language	English
Pages (from-to)	380-388
Number of pages	9
Journal	International Journal of Antimicrobial Agents
Volume	29
Issue number	4
DOIs	https://doi.org/10.1016/j.ijantimicag.2006.10.008
Publication status	Published - Apr 2007

Keywords

Antimicrobial resistance
Metallo-β-lactamases

ASJC Scopus subject areas

Applied Microbiology and Biotechnology
Microbiology
Parasitology
Virology
Immunology and Allergy
Infectious Diseases

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Cornaglia, G., Akova, M., Amicosante, G., Cantón, R., Cauda, R., Docquier, J. D., Edelstein, M., Frère, J. M., Fuzi, M., Galleni, M., Giamarellou, H., Gniadkowski, M., Koncan, R., Libisch, B., Luzzaro, F., Miriagou, V., Navarro, F., Nordmann, P., Pagani, L., ... Rossolini, G. M. (2007). Metallo-β-lactamases as emerging resistance determinants in Gram-negative pathogens: open issues. International Journal of Antimicrobial Agents, 29(4), 380-388. https://doi.org/10.1016/j.ijantimicag.2006.10.008

Metallo-β-lactamases as emerging resistance determinants in Gram-negative pathogens : open issues. / Cornaglia, Giuseppe; Akova, Murat; Amicosante, Gianfranco; Cantón, Rafael; Cauda, Roberto; Docquier, Jean Denis; Edelstein, Mikhail; Frère, Jean Marie; Fuzi, Miklós; Galleni, Moreno; Giamarellou, Helen; Gniadkowski, Marek; Koncan, Raffaella; Libisch, Balázs; Luzzaro, Francesco; Miriagou, Vivi; Navarro, Ferran; Nordmann, Patrice; Pagani, Laura; Peixe, Luisa; Poirel, Laurent; Souli, Maria; Tacconelli, Evelina; Vatopoulos, Alkiviadis; Rossolini, Gian Maria.

In: International Journal of Antimicrobial Agents, Vol. 29, No. 4, 04.2007, p. 380-388.

Research output: Contribution to journal › Article › peer-review

Cornaglia, G, Akova, M, Amicosante, G, Cantón, R, Cauda, R, Docquier, JD, Edelstein, M, Frère, JM, Fuzi, M, Galleni, M, Giamarellou, H, Gniadkowski, M, Koncan, R, Libisch, B, Luzzaro, F, Miriagou, V, Navarro, F, Nordmann, P, Pagani, L, Peixe, L, Poirel, L, Souli, M, Tacconelli, E, Vatopoulos, A & Rossolini, GM 2007, 'Metallo-β-lactamases as emerging resistance determinants in Gram-negative pathogens: open issues', International Journal of Antimicrobial Agents, vol. 29, no. 4, pp. 380-388. https://doi.org/10.1016/j.ijantimicag.2006.10.008

Cornaglia, Giuseppe ; Akova, Murat ; Amicosante, Gianfranco ; Cantón, Rafael ; Cauda, Roberto ; Docquier, Jean Denis ; Edelstein, Mikhail ; Frère, Jean Marie ; Fuzi, Miklós ; Galleni, Moreno ; Giamarellou, Helen ; Gniadkowski, Marek ; Koncan, Raffaella ; Libisch, Balázs ; Luzzaro, Francesco ; Miriagou, Vivi ; Navarro, Ferran ; Nordmann, Patrice ; Pagani, Laura ; Peixe, Luisa ; Poirel, Laurent ; Souli, Maria ; Tacconelli, Evelina ; Vatopoulos, Alkiviadis ; Rossolini, Gian Maria. / Metallo-β-lactamases as emerging resistance determinants in Gram-negative pathogens : open issues. In: International Journal of Antimicrobial Agents. 2007 ; Vol. 29, No. 4. pp. 380-388.

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