Metallo-β-lactamases as emerging resistance determinants in Gram-negative pathogens: open issues

Giuseppe Cornaglia, Murat Akova, Gianfranco Amicosante, Rafael Cantón, Roberto Cauda, Jean Denis Docquier, Mikhail Edelstein, Jean Marie Frère, Miklós Fuzi, Moreno Galleni, Helen Giamarellou, Marek Gniadkowski, Raffaella Koncan, Balázs Libisch, Francesco Luzzaro, Vivi Miriagou, Ferran Navarro, Patrice Nordmann, Laura Pagani, Luisa PeixeLaurent Poirel, Maria Souli, Evelina Tacconelli, Alkiviadis Vatopoulos, Gian Maria Rossolini

Research output: Contribution to journalArticlepeer-review


The rapid spread of acquired metallo-β-lactamases (MBLs) among major Gram-negative pathogens is a matter of particular concern worldwide and primarily in Europe, one of first continents where the emergence of acquired MBLs has been reported and possibly the geographical area where the increasing diversity of these enzymes and the number of bacterial species affected are most impressive. This spread has not been paralleled by accuracy/standardisation of detection methods, completeness of epidemiological knowledge or a clear understanding of what MBL production entails in terms of clinical impact, hospital infection control and antimicrobial chemotherapy. A number of European experts in the field met to review the current knowledge on this phenomenon, to point out open issues and to reinforce and relate to one another the existing activities set forth by research institutes, scientific societies and European Union-driven networks.

Original languageEnglish
Pages (from-to)380-388
Number of pages9
JournalInternational Journal of Antimicrobial Agents
Issue number4
Publication statusPublished - Apr 2007


  • Antimicrobial resistance
  • Metallo-β-lactamases

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases


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