TY - JOUR
T1 - Metalloproteinases in diabetics and nondiabetics during acute coronary syndromes and after 3 months
AU - Derosa, Giuseppe
AU - Cicero, Arrigo
AU - Scalise, Filippo
AU - Avanzini, Maria
AU - Tinelli, Carmine
AU - Peros, Emmanouil
AU - Fogari, Elena
AU - D'Angelo, Angela
PY - 2007/7
Y1 - 2007/7
N2 - The authors hypothesized that matrix metalloproteinase (MMP)-2, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-1, and TIMP-2 would be abnormal in acute coronary syndromes (ACS). Forty-six diabetic and 78 nondiabetic patients during ACS and after 3 months were enrolled in this study. MMP-2, -9 and TIMP-1, -2 plasma levels were measured. Significant decrease of MMP-2, TIMP-1, and TIMP-2 plasma levels was observed in the nondiabetic group with ACS after 3 months compared to the baseline value. Significant decrease of MMP-2, MMP-9, TIMP-1, and TIMP-2 plasma levels was observed in the diabetic group with ACS after 3 months compared to the baseline value. MMP-9, TIMP-1, and TIMP-2 plasma levels were higher in diabetic patients during ACS compared to nondiabetic patients during ACS. TIMP-1 and TIMP-2 increases were observed in diabetic patients with ACS at 3 months compared to nondiabetic patients after ACS. MMPs and TIMP-1 and -2 plasma levels were alterated in nondiabetic and diabetic patients during ACS and after 3 months, which may reflect abnormal extracellular matrix metabolism in diabetes during and after acute event.
AB - The authors hypothesized that matrix metalloproteinase (MMP)-2, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-1, and TIMP-2 would be abnormal in acute coronary syndromes (ACS). Forty-six diabetic and 78 nondiabetic patients during ACS and after 3 months were enrolled in this study. MMP-2, -9 and TIMP-1, -2 plasma levels were measured. Significant decrease of MMP-2, TIMP-1, and TIMP-2 plasma levels was observed in the nondiabetic group with ACS after 3 months compared to the baseline value. Significant decrease of MMP-2, MMP-9, TIMP-1, and TIMP-2 plasma levels was observed in the diabetic group with ACS after 3 months compared to the baseline value. MMP-9, TIMP-1, and TIMP-2 plasma levels were higher in diabetic patients during ACS compared to nondiabetic patients during ACS. TIMP-1 and TIMP-2 increases were observed in diabetic patients with ACS at 3 months compared to nondiabetic patients after ACS. MMPs and TIMP-1 and -2 plasma levels were alterated in nondiabetic and diabetic patients during ACS and after 3 months, which may reflect abnormal extracellular matrix metabolism in diabetes during and after acute event.
KW - Acute Coronary Syndromes
KW - Diabetes Mellitus
KW - Extracellular Matrix
KW - Matrix Metalloproteinases
KW - Tissue Inhibitors of Metalloproteinases
UR - http://www.scopus.com/inward/record.url?scp=35148862693&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35148862693&partnerID=8YFLogxK
U2 - 10.1080/10623320701606475
DO - 10.1080/10623320701606475
M3 - Article
C2 - 17922333
AN - SCOPUS:35148862693
VL - 14
SP - 175
EP - 183
JO - Endothelium: Journal of Endothelial Cell Research
JF - Endothelium: Journal of Endothelial Cell Research
SN - 1062-3329
IS - 4-5
ER -