Metalloproteinases in diabetics and nondiabetics during acute coronary syndromes and after 3 months

Giuseppe Derosa, Arrigo Cicero, Filippo Scalise, Maria Avanzini, Carmine Tinelli, Emmanouil Peros, Elena Fogari, Angela D'Angelo

Research output: Contribution to journalArticlepeer-review

Abstract

The authors hypothesized that matrix metalloproteinase (MMP)-2, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-1, and TIMP-2 would be abnormal in acute coronary syndromes (ACS). Forty-six diabetic and 78 nondiabetic patients during ACS and after 3 months were enrolled in this study. MMP-2, -9 and TIMP-1, -2 plasma levels were measured. Significant decrease of MMP-2, TIMP-1, and TIMP-2 plasma levels was observed in the nondiabetic group with ACS after 3 months compared to the baseline value. Significant decrease of MMP-2, MMP-9, TIMP-1, and TIMP-2 plasma levels was observed in the diabetic group with ACS after 3 months compared to the baseline value. MMP-9, TIMP-1, and TIMP-2 plasma levels were higher in diabetic patients during ACS compared to nondiabetic patients during ACS. TIMP-1 and TIMP-2 increases were observed in diabetic patients with ACS at 3 months compared to nondiabetic patients after ACS. MMPs and TIMP-1 and -2 plasma levels were alterated in nondiabetic and diabetic patients during ACS and after 3 months, which may reflect abnormal extracellular matrix metabolism in diabetes during and after acute event.

Original languageEnglish
Pages (from-to)175-183
Number of pages9
JournalEndothelium: Journal of Endothelial Cell Research
Volume14
Issue number4-5
DOIs
Publication statusPublished - Jul 2007

Keywords

  • Acute Coronary Syndromes
  • Diabetes Mellitus
  • Extracellular Matrix
  • Matrix Metalloproteinases
  • Tissue Inhibitors of Metalloproteinases

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

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