TY - JOUR
T1 - Metallothionein downregulation in very old age
T2 - A phenomenon associated with cellular senescence?
AU - Malavolta, Marco
AU - Cipriano, Catia
AU - Costarelli, Laura
AU - Giacconi, Robertina
AU - Tesei, Silvia
AU - Muti, Elisa
AU - Piacenza, Francesco
AU - Pierpaoli, Sara
AU - Larbi, Annis
AU - Pawelec, Graham
AU - Dedoussis, George
AU - Herbein, George
AU - Monti, Daniela
AU - Jajte, Jolanta
AU - Rink, Lothar
AU - Mocchegiani, Eugenio
PY - 2008/4/1
Y1 - 2008/4/1
N2 - It is known that metallothionein (MT) mRNA expression first increases with age, but then decreases again in the very elderly. Here we report that MT protein levels also decrease in very old age, and that this is independent of dietary zinc intake. Age-related changes of MT, as well as alterations of zinc homeostasis (intracellular labile zinc and NO-induced zinc release), occur both in human PBMCs ex vivo and also in CD4+ T cell clones progressing through their finite life span in vitro. These results suggest that phenomena observed in very old people can be at least partially attributed to diminished cell proliferation.
AB - It is known that metallothionein (MT) mRNA expression first increases with age, but then decreases again in the very elderly. Here we report that MT protein levels also decrease in very old age, and that this is independent of dietary zinc intake. Age-related changes of MT, as well as alterations of zinc homeostasis (intracellular labile zinc and NO-induced zinc release), occur both in human PBMCs ex vivo and also in CD4+ T cell clones progressing through their finite life span in vitro. These results suggest that phenomena observed in very old people can be at least partially attributed to diminished cell proliferation.
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U2 - 10.1089/rej.2008.0679
DO - 10.1089/rej.2008.0679
M3 - Article
C2 - 18393657
AN - SCOPUS:42649144123
VL - 11
SP - 455
EP - 459
JO - Rejuvenation Research
JF - Rejuvenation Research
SN - 1549-1684
IS - 2
ER -