Metallothionein downregulation in very old age: A phenomenon associated with cellular senescence?

Marco Malavolta; Catia Cipriano; Laura Costarelli; Robertina Giacconi; Silvia Tesei; Elisa Muti; Francesco Piacenza; Sara Pierpaoli; Annis Larbi; Graham Pawelec; George Dedoussis; George Herbein; Daniela Monti; Jolanta Jajte; Lothar Rink; Eugenio Mocchegiani

doi:10.1089/rej.2008.0679

Metallothionein downregulation in very old age: A phenomenon associated with cellular senescence?

Marco Malavolta, Catia Cipriano, Laura Costarelli, Robertina Giacconi, Silvia Tesei, Elisa Muti, Francesco Piacenza, Sara Pierpaoli, Annis Larbi, Graham Pawelec, George Dedoussis, George Herbein, Daniela Monti, Jolanta Jajte, Lothar Rink, Eugenio Mocchegiani

Istituto Nazionale di Riposo e Cura per Anziani V.E. II

Research output: Contribution to journal › Article › peer-review

Abstract

It is known that metallothionein (MT) mRNA expression first increases with age, but then decreases again in the very elderly. Here we report that MT protein levels also decrease in very old age, and that this is independent of dietary zinc intake. Age-related changes of MT, as well as alterations of zinc homeostasis (intracellular labile zinc and NO-induced zinc release), occur both in human PBMCs ex vivo and also in CD4+ T cell clones progressing through their finite life span in vitro. These results suggest that phenomena observed in very old people can be at least partially attributed to diminished cell proliferation.

Original language	English
Pages (from-to)	455-459
Number of pages	5
Journal	Rejuvenation Research
Volume	11
Issue number	2
DOIs	https://doi.org/10.1089/rej.2008.0679
Publication status	Published - Apr 1 2008

ASJC Scopus subject areas

Ageing

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Malavolta, M., Cipriano, C., Costarelli, L., Giacconi, R., Tesei, S., Muti, E., Piacenza, F., Pierpaoli, S., Larbi, A., Pawelec, G., Dedoussis, G., Herbein, G., Monti, D., Jajte, J., Rink, L., & Mocchegiani, E. (2008). Metallothionein downregulation in very old age: A phenomenon associated with cellular senescence? Rejuvenation Research, 11(2), 455-459. https://doi.org/10.1089/rej.2008.0679

Malavolta, M, Cipriano, C, Costarelli, L, Giacconi, R, Tesei, S, Muti, E, Piacenza, F, Pierpaoli, S, Larbi, A, Pawelec, G, Dedoussis, G, Herbein, G, Monti, D, Jajte, J, Rink, L & Mocchegiani, E 2008, 'Metallothionein downregulation in very old age: A phenomenon associated with cellular senescence?', Rejuvenation Research, vol. 11, no. 2, pp. 455-459. https://doi.org/10.1089/rej.2008.0679

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title = "Metallothionein downregulation in very old age: A phenomenon associated with cellular senescence?",

abstract = "It is known that metallothionein (MT) mRNA expression first increases with age, but then decreases again in the very elderly. Here we report that MT protein levels also decrease in very old age, and that this is independent of dietary zinc intake. Age-related changes of MT, as well as alterations of zinc homeostasis (intracellular labile zinc and NO-induced zinc release), occur both in human PBMCs ex vivo and also in CD4+ T cell clones progressing through their finite life span in vitro. These results suggest that phenomena observed in very old people can be at least partially attributed to diminished cell proliferation.",

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AU - Malavolta, Marco

AU - Cipriano, Catia

AU - Costarelli, Laura

AU - Giacconi, Robertina

AU - Tesei, Silvia

AU - Muti, Elisa

AU - Piacenza, Francesco

AU - Pierpaoli, Sara

AU - Larbi, Annis

AU - Pawelec, Graham

AU - Dedoussis, George

AU - Herbein, George

AU - Monti, Daniela

AU - Jajte, Jolanta

AU - Rink, Lothar

AU - Mocchegiani, Eugenio

PY - 2008/4/1

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N2 - It is known that metallothionein (MT) mRNA expression first increases with age, but then decreases again in the very elderly. Here we report that MT protein levels also decrease in very old age, and that this is independent of dietary zinc intake. Age-related changes of MT, as well as alterations of zinc homeostasis (intracellular labile zinc and NO-induced zinc release), occur both in human PBMCs ex vivo and also in CD4+ T cell clones progressing through their finite life span in vitro. These results suggest that phenomena observed in very old people can be at least partially attributed to diminished cell proliferation.

AB - It is known that metallothionein (MT) mRNA expression first increases with age, but then decreases again in the very elderly. Here we report that MT protein levels also decrease in very old age, and that this is independent of dietary zinc intake. Age-related changes of MT, as well as alterations of zinc homeostasis (intracellular labile zinc and NO-induced zinc release), occur both in human PBMCs ex vivo and also in CD4+ T cell clones progressing through their finite life span in vitro. These results suggest that phenomena observed in very old people can be at least partially attributed to diminished cell proliferation.

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Metallothionein downregulation in very old age: A phenomenon associated with cellular senescence?

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