Metallothionein downregulation in very old age: A phenomenon associated with cellular senescence?

Marco Malavolta, Catia Cipriano, Laura Costarelli, Robertina Giacconi, Silvia Tesei, Elisa Muti, Francesco Piacenza, Sara Pierpaoli, Annis Larbi, Graham Pawelec, George Dedoussis, George Herbein, Daniela Monti, Jolanta Jajte, Lothar Rink, Eugenio Mocchegiani

Research output: Contribution to journalArticlepeer-review

Abstract

It is known that metallothionein (MT) mRNA expression first increases with age, but then decreases again in the very elderly. Here we report that MT protein levels also decrease in very old age, and that this is independent of dietary zinc intake. Age-related changes of MT, as well as alterations of zinc homeostasis (intracellular labile zinc and NO-induced zinc release), occur both in human PBMCs ex vivo and also in CD4+ T cell clones progressing through their finite life span in vitro. These results suggest that phenomena observed in very old people can be at least partially attributed to diminished cell proliferation.

Original languageEnglish
Pages (from-to)455-459
Number of pages5
JournalRejuvenation Research
Volume11
Issue number2
DOIs
Publication statusPublished - Apr 1 2008

ASJC Scopus subject areas

  • Ageing

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