Metals and oxidative stress in patients with Parkinson's disease

Giovanni Forte, Alessandro Alimonti, Anna Pino, Paolo Stanzione, Sonia Brescianini, Livia Brusa, Giuseppe Sancesario, Nicola Violante, Beatrice Bocca

Research output: Contribution to journalArticlepeer-review

Abstract

Twenty-six metals and the oxidative status in 71 patients affected by Parkinson's disease and 44 healthy individuals were compared in order to identify potential biomarkers of the disease. In the patients, the following significant imbalances were found (p ≤ 0.05): i) in serum, an increment of Ca, Mg, Ni, Si and V, and a decrement of Cd, Co, Fe, Li, Sn, Zn and Zr; ii) in blood, raised levels of Co, Li, Ni and Si and decreased of Al, Be, Ca, Cd, Fe, Mg, Mo, Sn, Zn and Zr; iii) increased formation of oxidant species and lowered anti-oxidant capacity (p ≤ 0.001 for both). Barium, Bi, Cr, Cu, Hg, Mn, Pb, Sb, Sr, Tl and W did not change with the disease. The best discriminating variables between patients and controls were Cd, Co, Fe, Ni and Si in serum (91.2% of cases correctly classified), and Al, Cd, Co, Fe, Mo and Si in blood (98.2% of cases properly classified).

Original languageEnglish
Pages (from-to)189-195
Number of pages7
JournalAnnali dell'Istituto Superiore di Sanita
Volume41
Issue number2
Publication statusPublished - 2005

Keywords

  • Blood
  • Metals
  • Oxidative status
  • Parkinson's disease
  • Serum

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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