Metastasis of malignant peritoneal epithelioid mesothelioma in endoscopic gastric biopsy: A diagnostic pitfall

Lorenzo Daniele, Alberto Righi, Andrea Ferraris, Luigia Macrì, Sofia Asioli

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To describe a case of metastasis of malignant peritoneal epithelioid mesothelioma in gastric antral mucosa in a patient with a cryptogenic liver cirrhosis associated with esophageal varices, abdominal pain and distension, ascites, and weight loss. Materials and method: The patient underwent esophageal gastric endoscopy for varices, and a biopsy of a polypoid antral lesion was performed. The latter revealed a proliferation of polygonal cells with moderately atypical nuclei and pale eosinophilic, peripherally condensed cytoplasm infiltrating into the lamina propria between the normal mucosal glands of the antrum. The tumor cells were diffusely positive to anticalretinin antibody, whereas anti-claudin 4 and anti-CEA antisera were negative. Conclusions: Metastases of malignant peritoneal mesotheliomas are unusual, and a predominantly gastrointestinal localization is rare. Pathologists should be aware of this possibility to avoid misdiagnosis, particularly in small biopsy specimens.

Original languageEnglish
Pages (from-to)217-219
Number of pages3
JournalInternational Journal of Surgical Pathology
Volume19
Issue number2
DOIs
Publication statusPublished - Apr 2011

Keywords

  • endoscopic
  • epithelioid
  • gastrointestinal
  • mesothelioma
  • metastasis

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

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