Abstract
BACKGROUND: Multiple primary tumors in the same patient are reported to occur in the range of 2–17%. Histopathological recognition of an unsuspected tumor is important as it could influence therapeutic decisions and affect patients’ prognosis, but synchronous concomitant malignancies can be a diagnostic challenge for the pathologist. CASE: We report a case of prostatic acinar adenocarcinoma metastatic to a pelvic lymph node also affected by Hodgkin disease in a 73yearold man. After prostatic biopsies positive for prostatic adenocarcinoma, the patient underwent a radical prostatectomy with bilateral pelvic lymphadenectomy. Pathological examination confirmed the initial diagnosis, revealing a bilateral highgrade prostatic adenocarcinoma involving about 70% of the prostate with extensive extracapsular invasion. A metastasis of prostatic adenocarcinoma was found in 1 of the left pelvic lymph nodes; all pelvic lymph nodes showed an architectural effacement due to a distinct neoplastic proliferation characterized by large cells consistent with ReedSternberg and Hodgkin cells, confirmed by immunohistochemistry reactions. CONCLUSION: This case is, to the best of our knowledge, the first case of a urological neoplasm, namely a prostatic acinar adenocarcinoma, metastasizing to a lymph node simultaneously involved by Hodgkin disease.
Original language | English |
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Pages (from-to) | 33-37 |
Number of pages | 5 |
Journal | Analytical and Quantitative Cytopathology and Histopathology |
Volume | 41 |
Issue number | 1 |
Publication status | Published - Jan 1 2019 |
Keywords
- Adenocarcinoma
- Collision metastasis
- Hodgkin lymphoma
- Lymph node
- Metastasis
- Pelvic lymph node
- Prostate
- Prostate cancer
- Prostatic adenocarcinoma
- Prostatic neoplasms
ASJC Scopus subject areas
- Histology
- Pathology and Forensic Medicine
- Cell Biology