Metastasis of prostatic adenocarcinoma in a lymph node affected by Hodgkin lymphoma

Nataniele Piol, Rita Bianchi, Francesca Pitto, Marco Mora, Carlo Terrone, Valerio G. Vellone, Antonio Lopez-Beltran, Carlo Toncini, Bruno Spina

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Multiple primary tumors in the same patient are reported to occur in the range of 2–17%. Histopathological recognition of an unsuspected tumor is important as it could influence therapeutic decisions and affect patients’ prognosis, but synchronous concomitant malignancies can be a diagnostic challenge for the pathologist. CASE: We report a case of prostatic acinar adenocarcinoma metastatic to a pelvic lymph node also affected by Hodgkin disease in a 73yearold man. After prostatic biopsies positive for prostatic adenocarcinoma, the patient underwent a radical prostatectomy with bilateral pelvic lymphadenectomy. Pathological examination confirmed the initial diagnosis, revealing a bilateral highgrade prostatic adenocarcinoma involving about 70% of the prostate with extensive extracapsular invasion. A metastasis of prostatic adenocarcinoma was found in 1 of the left pelvic lymph nodes; all pelvic lymph nodes showed an architectural effacement due to a distinct neoplastic proliferation characterized by large cells consistent with ReedSternberg and Hodgkin cells, confirmed by immunohistochemistry reactions. CONCLUSION: This case is, to the best of our knowledge, the first case of a urological neoplasm, namely a prostatic acinar adenocarcinoma, metastasizing to a lymph node simultaneously involved by Hodgkin disease.

Original languageEnglish
Pages (from-to)33-37
Number of pages5
JournalAnalytical and Quantitative Cytopathology and Histopathology
Volume41
Issue number1
Publication statusPublished - Jan 1 2019

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Keywords

  • Adenocarcinoma
  • Collision metastasis
  • Hodgkin lymphoma
  • Lymph node
  • Metastasis
  • Pelvic lymph node
  • Prostate
  • Prostate cancer
  • Prostatic adenocarcinoma
  • Prostatic neoplasms

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine
  • Cell Biology

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