Metastasis of the epididymis and spermatic cord from pancreatic adenocarcinoma: A rare entity. Description of a case and revision of literature

Carmelo Agostino Di Franco, Bruno Rovereto, Daniele Porru, Valeria Zoccarato, Cesare Regina, Tiziano Cebrelli, Nicolò Fiorello, Alessandra Viglio, Lavinia Galvagno, Carlo Marchetti, Andrea Ringressi, Davide Barletta, Giovanni Giliberto

Research output: Contribution to journalReview article

Abstract

Introduction: Metastatic epididymal and spermatic cord adenocarcinoma from epithelial tumors are a rare condition. The most frequent primary cancers are prostate, lung, kidney, gastrointestinal tumors and breast. In literature, there are very low number of cases reporting metastasis from pancreatic cancer to epididymis and spermatic cord. Case description: We report a case of 70-years old man with history of left orchiectomy for undescended testicle, who presented to our department with a palpable nodule in the right scrotum. Scrotal ultrasound revealed an inhomogeneous hypoechoic nodule of epididymis and/or spermatic cord. Neoplastic markers showed high levels of CEA (carcinoembryonic antigen) and bHCG (beta Human Chorionic Gonadotropin). The patient underwent right surgical scrotal exploration with orchifunicolectomy. Pathologic examination revealed pathologic tissue showing rare glandular structures. Immunohistochemistry profile was compatible with malign epithelial neoplasm with glandular differentiation. Total body CT-scan revealed pathologic tissue in pancreas between head and body and a suspect pathologic lesion in liver and 18-FDG PET-scan confirmed the pancreatic neoplastic mass and a suspect secondary hepatic lesion. Biopsy of pancreatic pathologic area was positive for ductal pancreatic adenocarcinoma. The patient was sent to oncologic evaluation and started chemotherapy. Conclusions: Malignancies of epididymis and spermatic cord are rare entities and, in literature, very low number of cases of metastasis from pancreatic carcinoma to epididymis and spermatic cord are described. Early differential diagnosis is fundamental mostly in those patients with age range unusual for testis cancers.

Original languageEnglish
Pages (from-to)72-73
Number of pages2
JournalArchivio Italiano di Urologia e Andrologia
Volume90
Issue number1
DOIs
Publication statusPublished - Jan 1 2018
Externally publishedYes

Fingerprint

Spermatic Cord
Epididymis
Adenocarcinoma
Neoplasm Metastasis
Scrotum
Glandular and Epithelial Neoplasms
Orchiectomy
Liver
Carcinoembryonic Antigen
Testicular Neoplasms
Patient Rights
Chorionic Gonadotropin
Pancreatic Neoplasms
Positron-Emission Tomography
Testis
Early Diagnosis
Pancreas
Lung Neoplasms
Neoplasms
Prostatic Neoplasms

Keywords

  • Adenocarcinoma
  • Epididymis cancer
  • Metastasis
  • Pancreatic cancer
  • Scrotal tumour
  • Spermatic cord cancer

ASJC Scopus subject areas

  • Urology

Cite this

Metastasis of the epididymis and spermatic cord from pancreatic adenocarcinoma : A rare entity. Description of a case and revision of literature. / Di Franco, Carmelo Agostino; Rovereto, Bruno; Porru, Daniele; Zoccarato, Valeria; Regina, Cesare; Cebrelli, Tiziano; Fiorello, Nicolò; Viglio, Alessandra; Galvagno, Lavinia; Marchetti, Carlo; Ringressi, Andrea; Barletta, Davide; Giliberto, Giovanni.

In: Archivio Italiano di Urologia e Andrologia, Vol. 90, No. 1, 01.01.2018, p. 72-73.

Research output: Contribution to journalReview article

@article{a6404efd6be644288f882ae15f52a7ed,
title = "Metastasis of the epididymis and spermatic cord from pancreatic adenocarcinoma: A rare entity. Description of a case and revision of literature",
abstract = "Introduction: Metastatic epididymal and spermatic cord adenocarcinoma from epithelial tumors are a rare condition. The most frequent primary cancers are prostate, lung, kidney, gastrointestinal tumors and breast. In literature, there are very low number of cases reporting metastasis from pancreatic cancer to epididymis and spermatic cord. Case description: We report a case of 70-years old man with history of left orchiectomy for undescended testicle, who presented to our department with a palpable nodule in the right scrotum. Scrotal ultrasound revealed an inhomogeneous hypoechoic nodule of epididymis and/or spermatic cord. Neoplastic markers showed high levels of CEA (carcinoembryonic antigen) and bHCG (beta Human Chorionic Gonadotropin). The patient underwent right surgical scrotal exploration with orchifunicolectomy. Pathologic examination revealed pathologic tissue showing rare glandular structures. Immunohistochemistry profile was compatible with malign epithelial neoplasm with glandular differentiation. Total body CT-scan revealed pathologic tissue in pancreas between head and body and a suspect pathologic lesion in liver and 18-FDG PET-scan confirmed the pancreatic neoplastic mass and a suspect secondary hepatic lesion. Biopsy of pancreatic pathologic area was positive for ductal pancreatic adenocarcinoma. The patient was sent to oncologic evaluation and started chemotherapy. Conclusions: Malignancies of epididymis and spermatic cord are rare entities and, in literature, very low number of cases of metastasis from pancreatic carcinoma to epididymis and spermatic cord are described. Early differential diagnosis is fundamental mostly in those patients with age range unusual for testis cancers.",
keywords = "Adenocarcinoma, Epididymis cancer, Metastasis, Pancreatic cancer, Scrotal tumour, Spermatic cord cancer",
author = "{Di Franco}, {Carmelo Agostino} and Bruno Rovereto and Daniele Porru and Valeria Zoccarato and Cesare Regina and Tiziano Cebrelli and Nicol{\`o} Fiorello and Alessandra Viglio and Lavinia Galvagno and Carlo Marchetti and Andrea Ringressi and Davide Barletta and Giovanni Giliberto",
year = "2018",
month = "1",
day = "1",
doi = "10.4081/aiua.2018.1.72",
language = "English",
volume = "90",
pages = "72--73",
journal = "Archivio italiano di urologia",
issn = "1124-3562",
publisher = "Edizioni Scripta Manent s.n.c.",
number = "1",

}

TY - JOUR

T1 - Metastasis of the epididymis and spermatic cord from pancreatic adenocarcinoma

T2 - A rare entity. Description of a case and revision of literature

AU - Di Franco, Carmelo Agostino

AU - Rovereto, Bruno

AU - Porru, Daniele

AU - Zoccarato, Valeria

AU - Regina, Cesare

AU - Cebrelli, Tiziano

AU - Fiorello, Nicolò

AU - Viglio, Alessandra

AU - Galvagno, Lavinia

AU - Marchetti, Carlo

AU - Ringressi, Andrea

AU - Barletta, Davide

AU - Giliberto, Giovanni

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Introduction: Metastatic epididymal and spermatic cord adenocarcinoma from epithelial tumors are a rare condition. The most frequent primary cancers are prostate, lung, kidney, gastrointestinal tumors and breast. In literature, there are very low number of cases reporting metastasis from pancreatic cancer to epididymis and spermatic cord. Case description: We report a case of 70-years old man with history of left orchiectomy for undescended testicle, who presented to our department with a palpable nodule in the right scrotum. Scrotal ultrasound revealed an inhomogeneous hypoechoic nodule of epididymis and/or spermatic cord. Neoplastic markers showed high levels of CEA (carcinoembryonic antigen) and bHCG (beta Human Chorionic Gonadotropin). The patient underwent right surgical scrotal exploration with orchifunicolectomy. Pathologic examination revealed pathologic tissue showing rare glandular structures. Immunohistochemistry profile was compatible with malign epithelial neoplasm with glandular differentiation. Total body CT-scan revealed pathologic tissue in pancreas between head and body and a suspect pathologic lesion in liver and 18-FDG PET-scan confirmed the pancreatic neoplastic mass and a suspect secondary hepatic lesion. Biopsy of pancreatic pathologic area was positive for ductal pancreatic adenocarcinoma. The patient was sent to oncologic evaluation and started chemotherapy. Conclusions: Malignancies of epididymis and spermatic cord are rare entities and, in literature, very low number of cases of metastasis from pancreatic carcinoma to epididymis and spermatic cord are described. Early differential diagnosis is fundamental mostly in those patients with age range unusual for testis cancers.

AB - Introduction: Metastatic epididymal and spermatic cord adenocarcinoma from epithelial tumors are a rare condition. The most frequent primary cancers are prostate, lung, kidney, gastrointestinal tumors and breast. In literature, there are very low number of cases reporting metastasis from pancreatic cancer to epididymis and spermatic cord. Case description: We report a case of 70-years old man with history of left orchiectomy for undescended testicle, who presented to our department with a palpable nodule in the right scrotum. Scrotal ultrasound revealed an inhomogeneous hypoechoic nodule of epididymis and/or spermatic cord. Neoplastic markers showed high levels of CEA (carcinoembryonic antigen) and bHCG (beta Human Chorionic Gonadotropin). The patient underwent right surgical scrotal exploration with orchifunicolectomy. Pathologic examination revealed pathologic tissue showing rare glandular structures. Immunohistochemistry profile was compatible with malign epithelial neoplasm with glandular differentiation. Total body CT-scan revealed pathologic tissue in pancreas between head and body and a suspect pathologic lesion in liver and 18-FDG PET-scan confirmed the pancreatic neoplastic mass and a suspect secondary hepatic lesion. Biopsy of pancreatic pathologic area was positive for ductal pancreatic adenocarcinoma. The patient was sent to oncologic evaluation and started chemotherapy. Conclusions: Malignancies of epididymis and spermatic cord are rare entities and, in literature, very low number of cases of metastasis from pancreatic carcinoma to epididymis and spermatic cord are described. Early differential diagnosis is fundamental mostly in those patients with age range unusual for testis cancers.

KW - Adenocarcinoma

KW - Epididymis cancer

KW - Metastasis

KW - Pancreatic cancer

KW - Scrotal tumour

KW - Spermatic cord cancer

UR - http://www.scopus.com/inward/record.url?scp=85050825146&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85050825146&partnerID=8YFLogxK

U2 - 10.4081/aiua.2018.1.72

DO - 10.4081/aiua.2018.1.72

M3 - Review article

AN - SCOPUS:85050825146

VL - 90

SP - 72

EP - 73

JO - Archivio italiano di urologia

JF - Archivio italiano di urologia

SN - 1124-3562

IS - 1

ER -