TY - JOUR
T1 - Metastatic angiosarcoma of the kidney
T2 - A case report with treatment approach and review of the literature
AU - Berretta, M.
AU - Rupolo, M.
AU - Buonadonna, A.
AU - Canzonieri, V.
AU - Brollo, A.
AU - Morra, A.
AU - Berretta, S.
AU - Bearz, A.
AU - Tirelli, U.
AU - Frustaci, Sergio
PY - 2006/4
Y1 - 2006/4
N2 - Angiosarcomas are rare soft tissue malignancies. Typically they originate from the skin of the scalp or face, whereas visceral sarcomas are very rare. We report the case of a 67-year-old man affected by a large angiosarcoma of the kidney. After surgical removal, a rapid peritoneal, visceral and cutaneous diffusion developed. Palliative chemotherapy, based on anthracycline and ifosfamide, which are normally used to treat all other high-grade spindle cell sarcomas, was totally inactive. On the basis of these results and of the biological characteristics of these rare neoplasms it is mandatory to develop other therapeutic approaches. Antiangiogenetic agents are of interest for this disease due to the peculiar origin of the cells of these sarcomas.
AB - Angiosarcomas are rare soft tissue malignancies. Typically they originate from the skin of the scalp or face, whereas visceral sarcomas are very rare. We report the case of a 67-year-old man affected by a large angiosarcoma of the kidney. After surgical removal, a rapid peritoneal, visceral and cutaneous diffusion developed. Palliative chemotherapy, based on anthracycline and ifosfamide, which are normally used to treat all other high-grade spindle cell sarcomas, was totally inactive. On the basis of these results and of the biological characteristics of these rare neoplasms it is mandatory to develop other therapeutic approaches. Antiangiogenetic agents are of interest for this disease due to the peculiar origin of the cells of these sarcomas.
KW - Angiosarcoma
KW - Chemotherapy
KW - Kidney
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M3 - Article
C2 - 16736893
AN - SCOPUS:33646863442
VL - 18
SP - 221
EP - 224
JO - Journal of Chemotherapy
JF - Journal of Chemotherapy
SN - 1120-009X
IS - 2
ER -