Metastatic chromophobe renal cell carcinoma treated with targeted therapies: A Renal Cross Channel Group study

Emeline Colomba, Gwénaël Le Teuff, Tim Eisen, Grant D Stewart, Kate Fife, James Larkin, Andrea Biondo, Lisa Pickering, Anandagopal Srinivasan, Helen Boyle, Lisa Derosa, Cora N Sternberg, Federica Recine, Christy Ralph, Carolina Saldana, Philippe Barthélémy, Jean Christophe Bernhard, Howard Gurney, Gregory Verhoest, Elodie VauleonPierre Bigot, Julien Berger, Christian Pfister, Gwenaelle Gravis, Jean-Michel Rodier, Stéphane Culine, Armelle Caty, Frederic Rolland, Franck Priou, Bernard Escudier, Laurence Albiges

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Treatment of non-clear cell renal cell carcinoma (RCC) remains controversial despite several recent prospective studies of targeted therapies (TT). Often Vascular Endothelial growth Factor (VEGF) and Mammalian Target of Rapamycin (mTOR) inhibitors are used, extrapolating the data from use of these agents in clear cell RCC.

METHODS: We performed a retrospective data analysis within the Renal Cross Channel Group to determine metastatic chromophobe RCC (mChRCC) outcomes in the TT era. The end-points were overall response, overall survival (OS) and time to treatment failure (TTF). The two latter were estimated using the Kaplan-Meier method.

RESULTS: 91 mChRCC patients from 26 centres were included. Median follow-up from the date of first metastasis was 6.1 years (range: 0-13.9). Median OS was 37.9 months (95% confidence interval [CI]: 21.4-46.8) from the diagnosis of metastatic disease. Among the 61 patients who received TT, 50 (82%) were treated with anti-angiogenic (AA) and 11 with mTOR inhibitors. Median TTF and OS in patients receiving a first line of AA was 8.7 months (95% CI: 5.2-10.9) and 22.9 months (95% CI: 17.8-49.2) versus 1.9 months (95% CI: 1.0-6.0) and 3.2 months (95% CI: 2.3-not evaluable) with mTOR inhibitors, respectively. A stratified log-rank test was used to compare AA and mTOR inhibitors TT, while controlling the effect of the International Metastatic RCC Database Consortium risk group and no significant difference between AA and mTOR inhibitors was observed for TTF (p = 0.26) or for OS (p = 0.55).

CONCLUSION: We report the largest retrospective cohort of patients with mChRCC treated with TT and no significant difference between AA and mTOR inhibitors was observed for TTF and OS.

Original languageEnglish
Pages (from-to)55-62
Number of pages8
JournalEuropean Journal of Cancer
Volume80
DOIs
Publication statusPublished - Jul 2017

Keywords

  • Adult
  • Aged
  • Angiogenesis Inhibitors
  • Antineoplastic Agents
  • Carcinoma, Renal Cell
  • Enzyme Inhibitors
  • Female
  • Humans
  • Kaplan-Meier Estimate
  • Kidney Neoplasms
  • Male
  • Middle Aged
  • Molecular Targeted Therapy
  • Retrospective Studies
  • Survival Analysis
  • TOR Serine-Threonine Kinases
  • Time Factors
  • Treatment Failure
  • Journal Article
  • Multicenter Study

Fingerprint Dive into the research topics of 'Metastatic chromophobe renal cell carcinoma treated with targeted therapies: A Renal Cross Channel Group study'. Together they form a unique fingerprint.

Cite this