Metastatic colorectal cancer: Prognostic and predictive factors

Research output: Contribution to journalReview articlepeer-review

Abstract

Colorectal cancer represents the third most frequently occurring cancer worldwide. In the last decade, the survival of patients affected by metastatic colorectal cancer (mCRC) has improved through the introduction of biological drugs. However, in this new and dynamic therapeutic context, research about prognostic and predictive factors is important to guide the oncologists to effective therapies as well as to improve the understanding of colorectal cancer biology. Their identification is an intensive area of research and our future goal will be to depict tumour-specific "molecular signa-tures" in order to predict the clinical course of the disease and the best treatments. In this report, we describe clinical, pathological and molecular biomarkers that can play a role as prognostic or predictive factors in mCRC.

Original languageEnglish
Pages (from-to)2779-2791
Number of pages13
JournalCurrent Medicinal Chemistry
Volume27
Issue number17
DOIs
Publication statusPublished - Jan 1 2020

Keywords

  • Biologic therapy
  • Chemotherapy
  • Colorectal cancer
  • Metastases
  • Predictive factors
  • Prognostic factors

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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