Metastatic colorectal cancer stimulates collagen synthesis by fibroblasts

D. Basso, S. Mazza, E. Greco, C. Belluco, G. Roveroni, F. Navaglia, D. Nitti, M. Lise, M. Plebani

Research output: Contribution to journalArticlepeer-review


Background: We ascertained in vitro whether there were any differences in the growth of fibroblasts and the production of collagen (PIIIP), in relation to the presence of conditioning sera or tumor tissues from colorectal cancer (CRC) patients with disease progression or regression after surgery. Ratients and Methods: Fibroblasts were conditioned with: 1) 10% of control (n=20) or CRC patients' (n=57) sera; 2) 10% of tumor tissue homogenates obtained from CRC patients without (group A, n=6) or with (group B, n=5) liver metastases. After surgery, 29/57 patients (group 1) developed while 28/57 (group 2) did not develop a recurrent disease. Results: The ratio between cell growth and PIIIP production increases when fibroblasts were conditioned by group 1 (p

Original languageEnglish
Pages (from-to)2665-2670
Number of pages6
JournalAnticancer Research
Issue number4 A
Publication statusPublished - 2001


  • Colorectal cancer
  • Fibroblasts
  • Metastasis
  • N-terminal propeptide of type III collagen

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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