Metastatic esthesioneuroblastoma secreting adrenocorticotropic hormone in pediatric patients

Silvestre Galioto, Alessandro Di Petrillo, Mauro Pastori, Alberto Arecchi

Research output: Contribution to journalArticle

Abstract

The purpose of this article was to report a pediatric case of secondary cervical esthesioneuroblastoma involving the parapharyngeal lymph nodes. A 3-year-old boy came to our clinical observation because of a right lymphonodal mass evidenced by nuclear magnetic resonance and a diagnosis of Cushing syndrome associated with ectopic adrenocorticotropic hormone secretion, moon face, central obesity, asthenia, and hirsutism. At the age of 10 months, the patient underwent endoscopic surgery for asportation of the World Health Organization stage IVesthesioneuroblastoma. At 38 months of age, the patient underwent right parapharyngeal lymphadenectomy with surgical access by a double mandibulectomy. After surgery, serum ACTH, cortisolemia, and urinary excretion of cortisol were within the reference range. Blood pressure was recorded at 110/70 mm Hg. Moon face disappeared, as well as central obesity and hirsutism. Clinical report is presented together with brief review of literature.

Original languageEnglish
Pages (from-to)1924-1929
Number of pages6
JournalJournal of Craniofacial Surgery
Volume22
Issue number5
DOIs
Publication statusPublished - Sep 2011

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Keywords

  • Cushing syndrome
  • Ectopic ACTH
  • Parapharyngeal lymph nodes metastasis
  • Pediatric esthesioneuroblastoma

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery

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