Metastatic osteosarcoma: a challenging multidisciplinary treatment

Research output: Contribution to journalArticle

Abstract

Osteosarcoma is the most common malignant bone tumor, currently treated with pre-and postoperative chemotherapy in association with the surgical removal of the tumor. About 15–20% of patients have evidence of metastases at diagnosis, mostly in the lungs. Patients with metastatic disease still have a very poor prognosis, with approximately 20–30% of long-term survivors, as compared with 65–70% of patients with localized disease. The optimum management of these patients has not been standardized yet due to several patterns of metastatic disease harboring different prognosis. Complete surgical resection of all sites of disease is mandatory and predictive of survival. Patients with multiple sites of disease not amenable to complete surgery removal should be considered for innovative therapeutic approaches because of poor prognosis.

Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalExpert Review of Anticancer Therapy
DOIs
Publication statusAccepted/In press - Apr 4 2016

Keywords

  • Chemotherapy
  • different patterns of disease
  • genomic complexity
  • multidisciplinary
  • surgery
  • survival
  • tailored therapy
  • targeted drugs

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Oncology

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