Metastatic placental site trophoblastic tumor: Report of a case with complete response to chemotherapy

G. Mangili, E. Garavaglia, P. De Marzi, F. Zanetto, G. Taccagni

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

BACKGROUND: Placental site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasia, commonly insensitive to chemotherapeutic agents. CASE: We report on long-term remission in a patient with metastatic PSTT after etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine combination chemotherapy. The 27-year-old patient with metastatic lung PSTT was alive, without evidence of disease, >40 months after treatment. CONCLUSION: Treatment with multiagent chemotherapy can produce long-term remission, even in patients with metastatic PSTT.

Original languageEnglish
Pages (from-to)259-262
Number of pages4
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume46
Issue number3
Publication statusPublished - 2001

Fingerprint

Placental Site Trophoblastic Tumor
Drug Therapy
Gestational Trophoblastic Disease
Dactinomycin
Vincristine
Etoposide
Combination Drug Therapy
Methotrexate
Cyclophosphamide
Lung
Therapeutics

Keywords

  • Combination chemotherapy
  • Metastasis
  • Placental-site trophoblastic tumor

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Metastatic placental site trophoblastic tumor : Report of a case with complete response to chemotherapy. / Mangili, G.; Garavaglia, E.; De Marzi, P.; Zanetto, F.; Taccagni, G.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 46, No. 3, 2001, p. 259-262.

Research output: Contribution to journalArticle

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AB - BACKGROUND: Placental site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasia, commonly insensitive to chemotherapeutic agents. CASE: We report on long-term remission in a patient with metastatic PSTT after etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine combination chemotherapy. The 27-year-old patient with metastatic lung PSTT was alive, without evidence of disease, >40 months after treatment. CONCLUSION: Treatment with multiagent chemotherapy can produce long-term remission, even in patients with metastatic PSTT.

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