Metastatic psammomatous somatostatinoma of the pancreas causing severe ketoacidotic diabetes cured by surgery

Fausto Sessa, Massimo Arcidiaco, Luigi Valenti, Marco Solcia, Enrico Di Maggio, Enrico Solcia

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A case of somatostatin-producing pancreatic tumor associated with severe insulin-dependent diabetes mellitus and ketoacidotic coma is reported. The tumor, a 10-cm expansile mass arising from the pancreatic tail of a 70-yr-old woman, was first detected by ultrasonography, performed because of abdominal pain, and subsequently confirmed by computed tomography and fine-needle tumor aspiration. Pathologic investigation showed a predominantly solid-trabecular structure with scattered microacini and psammomatous bodies. A large proportion of tumor cells expressed somatostatin and/or calcitonin. Following resection of the primary tumor and three peripancreatic lymph nodes with metastases, the patient recovered rapidly from her diabetic syndrome and remained in substantially good health during a subsequent 8-yr follow-up period, without evidence of tumor recurrence.

Original languageEnglish
Pages (from-to)327-333
Number of pages7
JournalEndocrine Pathology
Volume8
Issue number4
Publication statusPublished - Dec 1997

Fingerprint

Somatostatinoma
Pancreas
Neoplasms
Somatostatin-Secreting Cells
Calcitonin
Coma
Fine Needle Biopsy
Somatostatin
Type 1 Diabetes Mellitus
Abdominal Pain
Ultrasonography
Lymph Nodes
Tomography
Neoplasm Metastasis
Recurrence
Health

Keywords

  • Computed tomography
  • Diabetes mellitus
  • Histopathology
  • Ketoacidotic coma
  • Pancreatic somatostatinoma
  • Ultrasonography

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pathology and Forensic Medicine

Cite this

Metastatic psammomatous somatostatinoma of the pancreas causing severe ketoacidotic diabetes cured by surgery. / Sessa, Fausto; Arcidiaco, Massimo; Valenti, Luigi; Solcia, Marco; Di Maggio, Enrico; Solcia, Enrico.

In: Endocrine Pathology, Vol. 8, No. 4, 12.1997, p. 327-333.

Research output: Contribution to journalArticle

Sessa, Fausto ; Arcidiaco, Massimo ; Valenti, Luigi ; Solcia, Marco ; Di Maggio, Enrico ; Solcia, Enrico. / Metastatic psammomatous somatostatinoma of the pancreas causing severe ketoacidotic diabetes cured by surgery. In: Endocrine Pathology. 1997 ; Vol. 8, No. 4. pp. 327-333.
@article{62b4cf291c8c436bbbba71d4773b0275,
title = "Metastatic psammomatous somatostatinoma of the pancreas causing severe ketoacidotic diabetes cured by surgery",
abstract = "A case of somatostatin-producing pancreatic tumor associated with severe insulin-dependent diabetes mellitus and ketoacidotic coma is reported. The tumor, a 10-cm expansile mass arising from the pancreatic tail of a 70-yr-old woman, was first detected by ultrasonography, performed because of abdominal pain, and subsequently confirmed by computed tomography and fine-needle tumor aspiration. Pathologic investigation showed a predominantly solid-trabecular structure with scattered microacini and psammomatous bodies. A large proportion of tumor cells expressed somatostatin and/or calcitonin. Following resection of the primary tumor and three peripancreatic lymph nodes with metastases, the patient recovered rapidly from her diabetic syndrome and remained in substantially good health during a subsequent 8-yr follow-up period, without evidence of tumor recurrence.",
keywords = "Computed tomography, Diabetes mellitus, Histopathology, Ketoacidotic coma, Pancreatic somatostatinoma, Ultrasonography",
author = "Fausto Sessa and Massimo Arcidiaco and Luigi Valenti and Marco Solcia and {Di Maggio}, Enrico and Enrico Solcia",
year = "1997",
month = "12",
language = "English",
volume = "8",
pages = "327--333",
journal = "Endocrine Pathology",
issn = "1046-3976",
publisher = "Humana Press",
number = "4",

}

TY - JOUR

T1 - Metastatic psammomatous somatostatinoma of the pancreas causing severe ketoacidotic diabetes cured by surgery

AU - Sessa, Fausto

AU - Arcidiaco, Massimo

AU - Valenti, Luigi

AU - Solcia, Marco

AU - Di Maggio, Enrico

AU - Solcia, Enrico

PY - 1997/12

Y1 - 1997/12

N2 - A case of somatostatin-producing pancreatic tumor associated with severe insulin-dependent diabetes mellitus and ketoacidotic coma is reported. The tumor, a 10-cm expansile mass arising from the pancreatic tail of a 70-yr-old woman, was first detected by ultrasonography, performed because of abdominal pain, and subsequently confirmed by computed tomography and fine-needle tumor aspiration. Pathologic investigation showed a predominantly solid-trabecular structure with scattered microacini and psammomatous bodies. A large proportion of tumor cells expressed somatostatin and/or calcitonin. Following resection of the primary tumor and three peripancreatic lymph nodes with metastases, the patient recovered rapidly from her diabetic syndrome and remained in substantially good health during a subsequent 8-yr follow-up period, without evidence of tumor recurrence.

AB - A case of somatostatin-producing pancreatic tumor associated with severe insulin-dependent diabetes mellitus and ketoacidotic coma is reported. The tumor, a 10-cm expansile mass arising from the pancreatic tail of a 70-yr-old woman, was first detected by ultrasonography, performed because of abdominal pain, and subsequently confirmed by computed tomography and fine-needle tumor aspiration. Pathologic investigation showed a predominantly solid-trabecular structure with scattered microacini and psammomatous bodies. A large proportion of tumor cells expressed somatostatin and/or calcitonin. Following resection of the primary tumor and three peripancreatic lymph nodes with metastases, the patient recovered rapidly from her diabetic syndrome and remained in substantially good health during a subsequent 8-yr follow-up period, without evidence of tumor recurrence.

KW - Computed tomography

KW - Diabetes mellitus

KW - Histopathology

KW - Ketoacidotic coma

KW - Pancreatic somatostatinoma

KW - Ultrasonography

UR - http://www.scopus.com/inward/record.url?scp=26444462574&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=26444462574&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:26444462574

VL - 8

SP - 327

EP - 333

JO - Endocrine Pathology

JF - Endocrine Pathology

SN - 1046-3976

IS - 4

ER -