Abstract
A case of somatostatin-producing pancreatic tumor associated with severe insulin-dependent diabetes mellitus and ketoacidotic coma is reported. The tumor, a 10-cm expansile mass arising from the pancreatic tail of a 70-yr-old woman, was first detected by ultrasonography, performed because of abdominal pain, and subsequently confirmed by computed tomography and fine-needle tumor aspiration. Pathologic investigation showed a predominantly solid-trabecular structure with scattered microacini and psammomatous bodies. A large proportion of tumor cells expressed somatostatin and/or calcitonin. Following resection of the primary tumor and three peripancreatic lymph nodes with metastases, the patient recovered rapidly from her diabetic syndrome and remained in substantially good health during a subsequent 8-yr follow-up period, without evidence of tumor recurrence.
Original language | English |
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Pages (from-to) | 327-333 |
Number of pages | 7 |
Journal | Endocrine Pathology |
Volume | 8 |
Issue number | 4 |
Publication status | Published - Dec 1997 |
Keywords
- Computed tomography
- Diabetes mellitus
- Histopathology
- Ketoacidotic coma
- Pancreatic somatostatinoma
- Ultrasonography
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Pathology and Forensic Medicine