Metastatic psammomatous somatostatinoma of the pancreas causing severe ketoacidotic diabetes cured by surgery

Fausto Sessa, Massimo Arcidiaco, Luigi Valenti, Marco Solcia, Enrico Di Maggio, Enrico Solcia

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Abstract

A case of somatostatin-producing pancreatic tumor associated with severe insulin-dependent diabetes mellitus and ketoacidotic coma is reported. The tumor, a 10-cm expansile mass arising from the pancreatic tail of a 70-yr-old woman, was first detected by ultrasonography, performed because of abdominal pain, and subsequently confirmed by computed tomography and fine-needle tumor aspiration. Pathologic investigation showed a predominantly solid-trabecular structure with scattered microacini and psammomatous bodies. A large proportion of tumor cells expressed somatostatin and/or calcitonin. Following resection of the primary tumor and three peripancreatic lymph nodes with metastases, the patient recovered rapidly from her diabetic syndrome and remained in substantially good health during a subsequent 8-yr follow-up period, without evidence of tumor recurrence.

Original languageEnglish
Pages (from-to)327-333
Number of pages7
JournalEndocrine Pathology
Volume8
Issue number4
Publication statusPublished - Dec 1997

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Keywords

  • Computed tomography
  • Diabetes mellitus
  • Histopathology
  • Ketoacidotic coma
  • Pancreatic somatostatinoma
  • Ultrasonography

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pathology and Forensic Medicine

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