Metformin administration improves leukocyte count in women with polycystic ovary syndrome: A 6-month prospective study

Francesco Orio, Francesco Manguso, Sebastiano Di Biase, Angela Falbo, Francesco Giallauria, Donato Labella, Achille Tolino, Gaetano Lombardi, Annamaria Colao, Stefano Palomba

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Introduction: Polycystic ovary syndrome (PCOS) is a common disorder associated with a wide range of endocrine and metabolic abnormalities. Low-grade chronic inflammation is a related complication recently observed in PCOS. Increased white blood cell (WBC) count was previously reported in PCOS women. Objective: To evaluate the effects of six months metformin administration on WBC count in PCOS women. Patients and methods: Fifty normal-weight PCOS women without additional metabolic or cardiovascular diseases were enrolled and treated with metformin (850 mg twice daily) for 6 months in a prospective baseline-controlled clinical study. At baseline and after treatment, WBC count and C-reactive protein (CRP) were evaluated in each patient. The whole hormonal profile, serum insulin and glucose levels (at fasting and during a 75 g 2-h oral glucose tolerance test), serum lipid profile were also assessed. Results: A significant difference was observed in WBC count (7050 ± 552 vs 6080 ± 577 cell/mm3± S.D., P

Original languageEnglish
Pages (from-to)69-73
Number of pages5
JournalEuropean Journal of Endocrinology
Volume157
Issue number1
DOIs
Publication statusPublished - Jul 2007

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Polycystic Ovary Syndrome
Metformin
Leukocyte Count
Prospective Studies
Metabolic Diseases
Glucose Tolerance Test
Serum
C-Reactive Protein
Fasting
Cardiovascular Diseases
Insulin
Inflammation
Lipids
Weights and Measures
Glucose

ASJC Scopus subject areas

  • Endocrinology

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Metformin administration improves leukocyte count in women with polycystic ovary syndrome : A 6-month prospective study. / Orio, Francesco; Manguso, Francesco; Di Biase, Sebastiano; Falbo, Angela; Giallauria, Francesco; Labella, Donato; Tolino, Achille; Lombardi, Gaetano; Colao, Annamaria; Palomba, Stefano.

In: European Journal of Endocrinology, Vol. 157, No. 1, 07.2007, p. 69-73.

Research output: Contribution to journalArticle

Orio, F, Manguso, F, Di Biase, S, Falbo, A, Giallauria, F, Labella, D, Tolino, A, Lombardi, G, Colao, A & Palomba, S 2007, 'Metformin administration improves leukocyte count in women with polycystic ovary syndrome: A 6-month prospective study', European Journal of Endocrinology, vol. 157, no. 1, pp. 69-73. https://doi.org/10.1530/EJE-07-0133
Orio, Francesco ; Manguso, Francesco ; Di Biase, Sebastiano ; Falbo, Angela ; Giallauria, Francesco ; Labella, Donato ; Tolino, Achille ; Lombardi, Gaetano ; Colao, Annamaria ; Palomba, Stefano. / Metformin administration improves leukocyte count in women with polycystic ovary syndrome : A 6-month prospective study. In: European Journal of Endocrinology. 2007 ; Vol. 157, No. 1. pp. 69-73.
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AU - Manguso, Francesco

AU - Di Biase, Sebastiano

AU - Falbo, Angela

AU - Giallauria, Francesco

AU - Labella, Donato

AU - Tolino, Achille

AU - Lombardi, Gaetano

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