Metformin administration improves leukocyte count in women with polycystic ovary syndrome: A 6-month prospective study

Francesco Orio, Francesco Manguso, Sebastiano Di Biase, Angela Falbo, Francesco Giallauria, Donato Labella, Achille Tolino, Gaetano Lombardi, Annamaria Colao, Stefano Palomba

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Abstract

Introduction: Polycystic ovary syndrome (PCOS) is a common disorder associated with a wide range of endocrine and metabolic abnormalities. Low-grade chronic inflammation is a related complication recently observed in PCOS. Increased white blood cell (WBC) count was previously reported in PCOS women. Objective: To evaluate the effects of six months metformin administration on WBC count in PCOS women. Patients and methods: Fifty normal-weight PCOS women without additional metabolic or cardiovascular diseases were enrolled and treated with metformin (850 mg twice daily) for 6 months in a prospective baseline-controlled clinical study. At baseline and after treatment, WBC count and C-reactive protein (CRP) were evaluated in each patient. The whole hormonal profile, serum insulin and glucose levels (at fasting and during a 75 g 2-h oral glucose tolerance test), serum lipid profile were also assessed. Results: A significant difference was observed in WBC count (7050 ± 552 vs 6080 ± 577 cell/mm3± S.D., P

Original languageEnglish
Pages (from-to)69-73
Number of pages5
JournalEuropean Journal of Endocrinology
Volume157
Issue number1
DOIs
Publication statusPublished - Jul 2007

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ASJC Scopus subject areas

  • Endocrinology

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Orio, F., Manguso, F., Di Biase, S., Falbo, A., Giallauria, F., Labella, D., Tolino, A., Lombardi, G., Colao, A., & Palomba, S. (2007). Metformin administration improves leukocyte count in women with polycystic ovary syndrome: A 6-month prospective study. European Journal of Endocrinology, 157(1), 69-73. https://doi.org/10.1530/EJE-07-0133