Metformin administration in patients with polycystic ovary syndrome who receive gonadotropins for in vitro fertilization cycles: 10-year experience in a large infertile population

Stefano Palomba, Angela Falbo, Tiziana Russo, Annalisa Di Cello, Michele Morelli, Francesco Orio, Fulvio Cappiello, Achille Tolino, Fulvio Zullo

Research output: Contribution to journalArticle

Abstract

The study aim was to evaluate our personal experience regarding the use and the reproductive effect of metformin administration in a large population of infertile patients with polycystic ovary syndrome (PCOS) undergoing gonadotropins ovarian stimulation for in vitro fertilization (IVF). Infertile patients with PCOS undergoing gonadotropins ovarian stimulation with (metformin group, n=191) or without (control group, n=187) metformin and IVF were evaluated. Treatment characteristics, patients' data and reproductive outcomes were evaluated. In all cases, metformin with an immediate-release formulation was administered, and in most of cases it was given as pre- and co-treatment (74.9%) and at a dosage of 1700mg/day (59.7%). Stimulation length and gonadotropins doses were significantly (p

Original languageEnglish
Pages (from-to)81-86
Number of pages6
JournalGynecological Endocrinology
Volume28
Issue number2
DOIs
Publication statusPublished - Feb 2012

Keywords

  • Gonadotropins
  • Infertility
  • IVF
  • Metformin
  • PCOS

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Obstetrics and Gynaecology

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