Metformin administration versus laparoscopic ovarian diathermy in clomiphene citrate-resistant women with polycystic ovary syndrome: A prospective parallel randomized double-blind placebo-controlled trial

Stefano Palomba, Francesco Orio, Luciano Giovanni Nardo, Angela Falbo, Tiziana Russo, Domenico Corea, Patrizia Doldo, Gaetano Lombardi, Achille Tolino, Annamaria Colao, Fulvio Zullo

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Abstract

At present, it is unclear what the role is of laparoscopic ovarian diathermy (LOD) and of metformin administration as second-line treatments for ovulation induction in women with polycystic ovary syndrome (PCOS) after failure of clomiphene citrate (CC) treatment. The aim of the present study was to compare in a randomized double-blind placebo-controlled fashion the effectiveness of LOD with metformin administration in the treatment of CC-resistant women with PCOS. A total of 120 overweight primary infertile anovulatory CC-resistant women with PCOS were enrolled and randomized into two groups of treatment. Group A underwent diagnostic laparoscopy, whereas group B underwent LOD. At hospital discharge, the patients were treated for 6 months with metformin cloridrate (group A; 850 mg twice daily) or with multivitamins (group B). The ovulation, pregnancy, abortion, and live-birth rates were evaluated. At the end of the study, the total ovulation rate was not statistically different between both treatment groups (54.8 vs. 55.1% in groups A and B, respectively), whereas the pregnancy (18.6 vs. 13.4%), the abortion (15.4 vs. 29.0%), and the live-birth (82.1 vs. 64.5%) rates were significantly (P <0.05) different between the two groups. Our data show that metformin administration is more effective than LOD in overall reproductive outcomes in overweight infertile CC-resistant women with PCOS.

Original languageEnglish
Pages (from-to)4801-4809
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume89
Issue number10
DOIs
Publication statusPublished - Oct 2004

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Hyperthermia therapy
Diathermy
Clomiphene
Polycystic Ovary Syndrome
Metformin
Placebos
Ovulation
Laparoscopy
Therapeutics
Ovulation Induction
Live Birth
Pregnancy Rate
Pregnancy

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Metformin administration versus laparoscopic ovarian diathermy in clomiphene citrate-resistant women with polycystic ovary syndrome : A prospective parallel randomized double-blind placebo-controlled trial. / Palomba, Stefano; Orio, Francesco; Nardo, Luciano Giovanni; Falbo, Angela; Russo, Tiziana; Corea, Domenico; Doldo, Patrizia; Lombardi, Gaetano; Tolino, Achille; Colao, Annamaria; Zullo, Fulvio.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 89, No. 10, 10.2004, p. 4801-4809.

Research output: Contribution to journalArticle

Palomba, Stefano ; Orio, Francesco ; Nardo, Luciano Giovanni ; Falbo, Angela ; Russo, Tiziana ; Corea, Domenico ; Doldo, Patrizia ; Lombardi, Gaetano ; Tolino, Achille ; Colao, Annamaria ; Zullo, Fulvio. / Metformin administration versus laparoscopic ovarian diathermy in clomiphene citrate-resistant women with polycystic ovary syndrome : A prospective parallel randomized double-blind placebo-controlled trial. In: Journal of Clinical Endocrinology and Metabolism. 2004 ; Vol. 89, No. 10. pp. 4801-4809.
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