Metformin hydrochloride and recurrent miscarriage in a woman with polycystic ovary syndrome

Stefano Palomba, Angela Falbo, Francesco Orio, Tiziana Russo, Achille Tolino, Fulvio Zullo

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To report the effect of metformin treatment on a patient with recurrent miscarriage (RM) and polycystic ovary syndrome (PCOS). Design: Case report. Setting: University department of obstetrics and gynecology, Italy. Patient(s): A woman complaining of RM who had PCOS and insulin resistance. Intervention(s): Clinical, biochemical, and instrumental assessments. Main Outcome Measure(s): Administration of metformin hydrochloride before and throughout pregnancy. Result(s): After 3 months of treatment, the patient became pregnant. The pregnancy had a physiologic development, and at 39 weeks of gestation, the patient spontaneously delivered a healthy infant. Conclusion(s): Metformin has shown to be effective in an insulin-resistant PCOS woman with RM.

Original languageEnglish
JournalFertility and Sterility
Volume85
Issue number5
DOIs
Publication statusPublished - May 2006

Keywords

  • Abortion
  • insulin
  • metformin
  • PCOS
  • pregnancy
  • recurrent miscarriage

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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