Metformin reduces risk of ovarian hyperstimulation syndrome in patients with polycystic ovary syndrome during gonadotropin-stimulated in vitro fertilization cycles: A randomized, controlled trial

Stefano Palomba, Angela Falbo, Laura Carrillo, Maria Teresa Villani, Francesco Orio, Tiziana Russo, Annalisa Di Cello, Fulvio Cappiello, Sabina Capasso, Achille Tolino, Annamaria Colao, Pasquale Mastrantonio, Giovanni Battista La Sala, Fulvio Zullo, Ettore Cittadini

Research output: Contribution to journalArticle

Abstract

Objective: To test whether metformin administration reduces the incidence of ovarian hyperstimulation syndrome (OHSS) in infertile high-risk patients with polycystic ovary syndrome (PCOS) who have been treated with gonadotropins for IVF. Design: Parallel, randomized, double-blind, placebo-controlled clinical trial. Setting: Academic departments, general hospital, and IVF centers. Patient(s): One hundred twenty patients with PCOS at high risk for OHSS. Intervention(s): Gonadotropins ovarian stimulation for IVF and metformin (500 mg three times daily) or placebo tablets (three times daily). Main Outcome Measure(s): The primary end point of the current clinical trial was the rate of OHSS. Anthropometric and reproductive data were evaluated. Result(s): The total OHSS and cancellation rates were significantly reduced in patients treated with metformin. The relative risk for OHSS was of 0.28 (95% confidence interval, 0.11-0.67). With metformin the stimulation length and the total amount of gonadotropins used were significantly increased, whereas the peak E 2 levels were significantly reduced. Conclusion(s): In patients with PCOS who are at high risk for OHSS and who have been stimulated with gonadotropins for IVF cycles, metformin reduces the risk of OHSS by modulating the ovarian response to the stimulation.

Original languageEnglish
JournalFertility and Sterility
Volume96
Issue number6
DOIs
Publication statusPublished - Dec 2011

Keywords

  • Gonadotropins
  • infertility
  • IVF
  • metformin
  • OHSS
  • PCOS
  • sterility

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

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    Palomba, S., Falbo, A., Carrillo, L., Villani, M. T., Orio, F., Russo, T., Di Cello, A., Cappiello, F., Capasso, S., Tolino, A., Colao, A., Mastrantonio, P., La Sala, G. B., Zullo, F., & Cittadini, E. (2011). Metformin reduces risk of ovarian hyperstimulation syndrome in patients with polycystic ovary syndrome during gonadotropin-stimulated in vitro fertilization cycles: A randomized, controlled trial. Fertility and Sterility, 96(6). https://doi.org/10.1016/j.fertnstert.2011.09.020