Metformin treatment does not affect total leptin levels and free leptin index in obese patients with polycystic ovary syndrome

Daniela Romualdi, Giuseppe Campagna, Luigi Selvaggi, Rosa Cento, Caterina Proto, Antonio Lanzone, Maurizio Guido

Research output: Contribution to journalArticlepeer-review

Abstract

Leptin, particularly in its free form, is deeply involved in the regulation of energy balance. Insulin was suggested to influence plasmatic leptin levels and soluble leptin receptor in humans. However, this study indicates that metformin treatment, although improving insulin levels, does not exert a significant effect on either total leptin level or free leptin index in obese women with hyperinsulinemia and PCOS.

Original languageEnglish
Pages (from-to)1273-1276
Number of pages4
JournalFertility and Sterility
Volume89
Issue number5
DOIs
Publication statusPublished - May 2008

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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