Methamphetamine fails to alter the noradrenergic integrity of the heart: A comparison with the parkinsonism-inducing neurotoxin MPTP

Riccardo Ruffoli, Paola Soldani, Livia Pasquali, Stefano Ruggieri, Antonio Paparelli, Francesco Fornai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The chronic use of methamphetamine leads to cardiomyopathy and a nigrostriatal dopamine deficiency that partly mimics what occurs in Parkinson's disease. This study examines the cardiac effects occurring after chronic administration of methamphetamine and parkinsonism-inducing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Despite the similarities concerning the nigrostriatal dopamine denervation, methamphetamine failed to produce chronic norepinephrine depletion in the heart, thus contrasting with what occurs in Parkinson's disease or after administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. These data suggest that the chronic cardiovascular effects induced by methamphetamine rely on biochemical changes which differ from those activated by 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine or during the course of Parkinson's disease.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages337-344
Number of pages8
Volume1139
DOIs
Publication statusPublished - Oct 2008

Publication series

NameAnnals of the New York Academy of Sciences
Volume1139
ISSN (Print)00778923
ISSN (Electronic)17496632

Keywords

  • Cardiac noradrenergic innervation
  • Methamphetamine
  • MPTP
  • Parkinson's disease
  • Parkinsonian heart

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Ruffoli, R., Soldani, P., Pasquali, L., Ruggieri, S., Paparelli, A., & Fornai, F. (2008). Methamphetamine fails to alter the noradrenergic integrity of the heart: A comparison with the parkinsonism-inducing neurotoxin MPTP. In Annals of the New York Academy of Sciences (Vol. 1139, pp. 337-344). (Annals of the New York Academy of Sciences; Vol. 1139). https://doi.org/10.1196/annals.1432.017