Methisoprinol-effect on the replication cycle of human hepatitis A virus.

M. Divizia, A. Venuti, A. M. Degener, R. Perez-Bercoff, A. Panà

Research output: Contribution to journalArticlepeer-review


The antiviral activity of methisoprinol was investigated under different conditions using a strain of hepatitis A virus (HAV), that shows a strong cytopathic effect on the Frp/3 cell line 7-9 days post-infection. Treatment of Frp/3 at a dose range of 125-1200 micrograms/ml had no toxic effect and showed a dose dependent inhibition of the HAV replication cycle. At the methisoprinol dose of 500 micrograms/ml the cytopathic effect was completely abolished and HAV antigen production reduced by 50% as measured by indirect immunofluorescence (IIF) and commercial enzyme-linked assay (ELISA). The virus yield was virtually abolished at the highest dose employed (1000 micrograms/ml).

Original languageEnglish
Pages (from-to)323-328
Number of pages6
Issue number4
Publication statusPublished - Oct 1992

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology


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