Method development in forensic toxicology

Frank T. Peters, Dirk K. Wissenbach, Francesco Paolo Busardò, Emilia Marchei, Simona Pichini

Research output: Contribution to journalReview article

Abstract

Background: In the field of forensic toxicology, the quality of analytical methods is of great importance to ensure the reliability of results and to avoid unjustified legal consequences. A key to high quality analytical methods is a thorough method development. Methods: The presented article will provide an overview on the process of developing methods for forensic applications. Results: This includes the definition of the method’s purpose (e.g. qualitative vs quantitative) and the analytes to be included, choosing an appropriate sample matrix, setting up separation and detection systems as well as establishing a versatile sample preparation. Conclusion: Method development is concluded by an optimization process after which the new method is subject to method validation.

Original languageEnglish
Pages (from-to)5455-5467
Number of pages13
JournalCurrent Pharmaceutical Design
Volume23
Issue number36
DOIs
Publication statusPublished - Oct 1 2017

Keywords

  • Analytical methods
  • Forensic applications
  • Forensic toxicology
  • Hyphenated methods
  • Method development
  • Systematic toxicological analysis

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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