Method for intracellular magnetic labeling of human mononuclear cells using approved iron contrast agents

J. C. Sipe, M. Filippi, G. Martino, R. Furlan, M. A. Rocca, M. Rovaris, A. Bergami, J. Zyroff, G. Scotti, G. Comi

Research output: Contribution to journalArticlepeer-review

Abstract

A method for intracellular iron labeling of human mononuclear cells (lymphocytes and monocytes) for magnetic resonance imaging (MRI) using simple incubation of cells with approved MRI iron contrast agents is presented. Labeled cells can be detected by MRI in vitro, and this suggests the possibility that the technique could become a marker for in vivo lymphocyte and monocyte trafficking studies in acute inflammatory lesions such as those in Multiple Sclerosis.

Original languageEnglish
Pages (from-to)1521-1523
Number of pages3
JournalMagnetic Resonance Imaging
Volume17
Issue number10
DOIs
Publication statusPublished - Dec 1999

Keywords

  • Iron Labeling
  • Lymphocytes
  • Monocytes
  • Multiple Sclerosis

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

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