Methodological assessment of HCC literature

G. Daniele, N. Costa, V. Lorusso, J. Costa-Maia, I. Pache, M. Pirisi

Research output: Contribution to journalArticlepeer-review


Despite the fact that the hepatocellular carcinoma (HCC) represents a major health problem, very few interventions are available for this disease, and only sorafenib is approved for the treatment of advanced disease. Of note, only very few interventions have been thoroughly evaluated over time for HCC patients compared with several hundreds in other, equally highly lethal, tumours. Additionally, clinical trials in HCC have often been questioned for poor design and methodological issues. As a consequence, a gap between what is measured in clinical trials and what clinicians have to face in daily practice often occurs. As a result of this scenario, even the most recent guidelines for treatment of HCC patients use low strength evidence to make recommendations. In this review, we will discuss some of the potential methodological issues hindering a rational development of new treatments for HCC patients.

Original languageEnglish
Pages (from-to)6-14
Number of pages9
JournalAnnals of Oncology
Issue numberSUPPL.2
Publication statusPublished - Apr 2013


  • Clinical trials
  • Hepatocellular carcinoma
  • Methodology
  • Observational studies
  • Randomized
  • Sorafenib

ASJC Scopus subject areas

  • Oncology
  • Hematology


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