Abstract
Biological monitoring of low level exposure to pollutants is a very challenging analytical activity, and the quality of results is difficult to assess, especially when a certified reference material is unavailable. The aim of this work was to evaluate the reliability of the assays used to measure urinary benzene (Benz-U) and S-phenylmercapturic acid (SPMA), by applying an internal quality control protocol. Urine spot samples from 705 subjects who were either members of the general urban population, gasoline station attendants, or refinery plant workers were assayed for Benz-U and SPMA, using GC/MS and LC/MS/MS, with quantification limits of 15 ng/L and 0.10 μg/L. The median Benz-U concentration was 263 ng/L (60. -2789 ng/L, 5th. -95th percentile), and the median SPMA concentration was 0.19 μg/L (
Original language | English |
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Pages (from-to) | 2534-2540 |
Number of pages | 7 |
Journal | Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences |
Volume | 878 |
Issue number | 27 |
DOIs | |
Publication status | Published - Oct 2010 |
Keywords
- Low benzene exposure
- Quality control
- Urinary benzene
- Urinary S-phenylmercapturic acid
ASJC Scopus subject areas
- Biochemistry
- Analytical Chemistry
- Cell Biology
- Clinical Biochemistry