Abstract
The urinary excretion data after I.M. administration of water soluble lysine salt of Alclofenac were analysed by the techniques suggested by Niebergall, Wagner, Martin and Cuinmings. All methods used give similar estimates of both DU∞ and Kel with exception of the "Sigma minus" method when DU∞ obtained by "Rate Method" was utilized. Niebergall's method is preferred on the basis that it provides an accurate estimation of both DU∞ and Kel. These parameters, evaluated after administration of Alclofenac-lysinate, resulted in agreement with previously reported data obtained after administration of different pharmaceuticals of acidic drug.
Original language | English |
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Pages (from-to) | 91-96 |
Number of pages | 6 |
Journal | European Journal of Drug Metabolism and Pharmacokinetics |
Volume | 4 |
Issue number | 2 |
DOIs | |
Publication status | Published - Apr 1979 |
Keywords
- Alclofenac
- Estimation of DU
- Kel
- Man
- Urinary excretion
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)