Methods for evaluation of urinary excretion parameters of Alclofenac after I.M. administration of its water soluble lysine salt in man

Rodolfo Testa, Roberto Latini

Research output: Contribution to journalArticle

Abstract

The urinary excretion data after I.M. administration of water soluble lysine salt of Alclofenac were analysed by the techniques suggested by Niebergall, Wagner, Martin and Cuinmings. All methods used give similar estimates of both DU and Kel with exception of the "Sigma minus" method when DU obtained by "Rate Method" was utilized. Niebergall's method is preferred on the basis that it provides an accurate estimation of both DU and Kel. These parameters, evaluated after administration of Alclofenac-lysinate, resulted in agreement with previously reported data obtained after administration of different pharmaceuticals of acidic drug.

Original languageEnglish
Pages (from-to)91-96
Number of pages6
JournalEuropean Journal of Drug Metabolism and Pharmacokinetics
Volume4
Issue number2
DOIs
Publication statusPublished - Apr 1979

Keywords

  • Alclofenac
  • Estimation of DU
  • Kel
  • Man
  • Urinary excretion

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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