Methods for monitoring oxidative stress, lipid peroxidation and oxidation resistance of lipoproteins

Peter M. Abuja, Riccardo Albertini

Research output: Contribution to journalArticle

Abstract

After a brief discussion of lipid peroxidation mechanism and the action of antioxidants and their potential to exhibit prooxidant effects, we give an overview on the clinical relevance of oxidative stress parameters. Many diseases are associated with oxidative stress e.g. by radical damage, among them atherosclerosis, diabetes mellitus, chronic renal failure, rheumatoid athritis, and neurodegenerative diseases, and in many cases the investigation of parameters of oxidative stress has brought substantial insights into their pathogenesis. We then briefly review methods for the continuous monitoring of lipid peroxidation processes in vitro, which has helped in elucidating their mechanism and in some more detail cover such methods which have been proposed more recently to assess oxidative status and antioxidant activity in biological samples.

Original languageEnglish
Pages (from-to)1-17
Number of pages17
JournalClinica Chimica Acta
Volume306
Issue number1-2
DOIs
Publication statusPublished - 2001

Keywords

  • Lipid peroxidation
  • Lipoproteins
  • Oxidative stress

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

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