Methods in pharmacoepidemiology: A review of statistical analyses and data reporting in pediatric drug utilization studies

Marco Sequi, Rita Campi, Antonio Clavenna, Maurizio Bonati

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate the quality of data reporting and statistical methods performed in drug utilization studies in the pediatric population. Methods: Drug utilization studies evaluating all drug prescriptions to children and adolescents published between January 1994 and December 2011 were retrieved and analyzed. For each study, information on measures of exposure/consumption, the covariates considered, descriptive and inferential analyses, statistical tests, and methods of data reporting was extracted. An overall quality score was created for each study using a 12-item checklist that took into account the presence of outcome measures, covariates of measures, descriptive measures, statistical tests, and graphical representation. Results: A total of 22 studies were reviewed and analyzed. Of these, 20 studies reported at least one descriptive measure. The mean was the most commonly used measure (18 studies), but only five of these also reported the standard deviation. Statistical analyses were performed in 12 studies, with the chi-square test being the most commonly performed test. Graphs were presented in 14 papers. Sixteen papers reported the number of drug prescriptions and/or packages, and ten reported the prevalence of the drug prescription. The mean quality score was 8 (median 9). Only seven of the 22 studies received a score of ≥10, while four studies received a score of

Original languageEnglish
Pages (from-to)599-604
Number of pages6
JournalEuropean Journal of Clinical Pharmacology
Volume69
Issue number3
DOIs
Publication statusPublished - Mar 2013

Keywords

  • Adolescent
  • Child
  • Drug utilization
  • Pharmacoepidemiology
  • Review

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

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