Methotrexate as a possible trigger of macrophage activation syndrome in systemic juvenile idiopathic arthritis

A. Ravelli, M. C. Caria, S. Buratti, C. Malattia, F. Temporini, A. Martini

Research output: Contribution to journalArticle

Abstract

Macrophage activation syndrome (MAS) is a potentially life threatening complication of chronic rheumatic diseases, particularly systemic juvenile idiopathic arthritis (JIA). A number of triggers have been related to the development of MAS, including viral infections, nonsteroidal antiinflammatory drug therapy, and gold salt injections. We describe a patient with systemic JIA who developed MAS shortly after receiving methotrexate, suggesting that this drug can be regarded as a potential trigger of MAS in children with JIA.

Original languageEnglish
Pages (from-to)865-867
Number of pages3
JournalJournal of Rheumatology
Volume28
Issue number4
Publication statusPublished - 2001

Keywords

  • Hemophagocytosis
  • Juvenile arthritis
  • Macropage activation syndrome
  • Methotrexate

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Fingerprint Dive into the research topics of 'Methotrexate as a possible trigger of macrophage activation syndrome in systemic juvenile idiopathic arthritis'. Together they form a unique fingerprint.

  • Cite this