Methotrexate as a possible trigger of macrophage activation syndrome in systemic juvenile idiopathic arthritis

A. Ravelli, M. C. Caria, S. Buratti, C. Malattia, F. Temporini, A. Martini

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Macrophage activation syndrome (MAS) is a potentially life threatening complication of chronic rheumatic diseases, particularly systemic juvenile idiopathic arthritis (JIA). A number of triggers have been related to the development of MAS, including viral infections, nonsteroidal antiinflammatory drug therapy, and gold salt injections. We describe a patient with systemic JIA who developed MAS shortly after receiving methotrexate, suggesting that this drug can be regarded as a potential trigger of MAS in children with JIA.

Original languageEnglish
Pages (from-to)865-867
Number of pages3
JournalJournal of Rheumatology
Volume28
Issue number4
Publication statusPublished - 2001

Fingerprint

Macrophage Activation Syndrome
Juvenile Arthritis
Methotrexate
Virus Diseases
Rheumatic Diseases
Gold
Chronic Disease
Anti-Inflammatory Agents
Salts
Drug Therapy
Injections
Pharmaceutical Preparations

Keywords

  • Hemophagocytosis
  • Juvenile arthritis
  • Macropage activation syndrome
  • Methotrexate

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Methotrexate as a possible trigger of macrophage activation syndrome in systemic juvenile idiopathic arthritis. / Ravelli, A.; Caria, M. C.; Buratti, S.; Malattia, C.; Temporini, F.; Martini, A.

In: Journal of Rheumatology, Vol. 28, No. 4, 2001, p. 865-867.

Research output: Contribution to journalArticle

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