Methotrexate effects on enteric mucosa liver and pancreas of normal and bled rats

G. Celle; M. Dodero; I. Pannacciulli; G. Fresco; C. Mansi; V. Savarino; G. Bogliolo

doi:10.1016/0014-2964(75)90058-4

Methotrexate effects on enteric mucosa liver and pancreas of normal and bled rats

G. Celle, M. Dodero, I. Pannacciulli, G. Fresco, C. Mansi, V. Savarino, G. Bogliolo

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article

Abstract

The effects upon the enteric mucosa, liver and pancreas of normal and bled rats induced by methotrexate administered in one dose are reported. In normal rats, notwithstanding the severe enteric lesions, gross histological modifications of the liver and pancreas are absent. In rats made anemic by bleeding, the liver damage is marked with a diffuse fatty metamorphosis which reaches a peak at 48 hr after drug administration; in the pancreas there was only a pattern of mild cellular toxicity.

Original language	English
Journal	European Journal of Cancer (1965)
Volume	11
Issue number	5
DOIs	https://doi.org/10.1016/0014-2964(75)90058-4
Publication status	Published - 1975

ASJC Scopus subject areas

Oncology

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Celle, G., Dodero, M., Pannacciulli, I., Fresco, G., Mansi, C., Savarino, V., & Bogliolo, G. (1975). Methotrexate effects on enteric mucosa liver and pancreas of normal and bled rats. European Journal of Cancer (1965), 11(5). https://doi.org/10.1016/0014-2964(75)90058-4

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abstract = "The effects upon the enteric mucosa, liver and pancreas of normal and bled rats induced by methotrexate administered in one dose are reported. In normal rats, notwithstanding the severe enteric lesions, gross histological modifications of the liver and pancreas are absent. In rats made anemic by bleeding, the liver damage is marked with a diffuse fatty metamorphosis which reaches a peak at 48 hr after drug administration; in the pancreas there was only a pattern of mild cellular toxicity.",

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AU - Celle, G.

AU - Dodero, M.

AU - Pannacciulli, I.

AU - Fresco, G.

AU - Mansi, C.

AU - Savarino, V.

AU - Bogliolo, G.

PY - 1975

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