Abstract
The effects upon the enteric mucosa, liver and pancreas of normal and bled rats induced by methotrexate administered in one dose are reported. In normal rats, notwithstanding the severe enteric lesions, gross histological modifications of the liver and pancreas are absent. In rats made anemic by bleeding, the liver damage is marked with a diffuse fatty metamorphosis which reaches a peak at 48 hr after drug administration; in the pancreas there was only a pattern of mild cellular toxicity.
| Original language | English |
|---|---|
| Journal | European Journal of Cancer (1965) |
| Volume | 11 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1975 |
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ASJC Scopus subject areas
- Oncology
Cite this
Methotrexate effects on enteric mucosa liver and pancreas of normal and bled rats. / Celle, G.; Dodero, M.; Pannacciulli, I.; Fresco, G.; Mansi, C.; Savarino, V.; Bogliolo, G.
In: European Journal of Cancer (1965), Vol. 11, No. 5, 1975.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Methotrexate effects on enteric mucosa liver and pancreas of normal and bled rats
AU - Celle, G.
AU - Dodero, M.
AU - Pannacciulli, I.
AU - Fresco, G.
AU - Mansi, C.
AU - Savarino, V.
AU - Bogliolo, G.
PY - 1975
Y1 - 1975
N2 - The effects upon the enteric mucosa, liver and pancreas of normal and bled rats induced by methotrexate administered in one dose are reported. In normal rats, notwithstanding the severe enteric lesions, gross histological modifications of the liver and pancreas are absent. In rats made anemic by bleeding, the liver damage is marked with a diffuse fatty metamorphosis which reaches a peak at 48 hr after drug administration; in the pancreas there was only a pattern of mild cellular toxicity.
AB - The effects upon the enteric mucosa, liver and pancreas of normal and bled rats induced by methotrexate administered in one dose are reported. In normal rats, notwithstanding the severe enteric lesions, gross histological modifications of the liver and pancreas are absent. In rats made anemic by bleeding, the liver damage is marked with a diffuse fatty metamorphosis which reaches a peak at 48 hr after drug administration; in the pancreas there was only a pattern of mild cellular toxicity.
UR - http://www.scopus.com/inward/record.url?scp=0016837539&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016837539&partnerID=8YFLogxK
U2 - 10.1016/0014-2964(75)90058-4
DO - 10.1016/0014-2964(75)90058-4
M3 - Article
C2 - 1157821
AN - SCOPUS:0016837539
VL - 11
JO - European Journal of Cancer
JF - European Journal of Cancer
SN - 0014-2964
IS - 5
ER -