Methotrexate effects on enteric mucosa liver and pancreas of normal and bled rats

G. Celle, M. Dodero, I. Pannacciulli, G. Fresco, C. Mansi, V. Savarino, G. Bogliolo

Research output: Contribution to journalArticle

Abstract

The effects upon the enteric mucosa, liver and pancreas of normal and bled rats induced by methotrexate administered in one dose are reported. In normal rats, notwithstanding the severe enteric lesions, gross histological modifications of the liver and pancreas are absent. In rats made anemic by bleeding, the liver damage is marked with a diffuse fatty metamorphosis which reaches a peak at 48 hr after drug administration; in the pancreas there was only a pattern of mild cellular toxicity.

Original languageEnglish
JournalEuropean Journal of Cancer (1965)
Volume11
Issue number5
DOIs
Publication statusPublished - 1975

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Methotrexate
Pancreas
Mucous Membrane
Liver
Hemorrhage
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Oncology

Cite this

Celle, G., Dodero, M., Pannacciulli, I., Fresco, G., Mansi, C., Savarino, V., & Bogliolo, G. (1975). Methotrexate effects on enteric mucosa liver and pancreas of normal and bled rats. European Journal of Cancer (1965), 11(5). https://doi.org/10.1016/0014-2964(75)90058-4

Methotrexate effects on enteric mucosa liver and pancreas of normal and bled rats. / Celle, G.; Dodero, M.; Pannacciulli, I.; Fresco, G.; Mansi, C.; Savarino, V.; Bogliolo, G.

In: European Journal of Cancer (1965), Vol. 11, No. 5, 1975.

Research output: Contribution to journalArticle

Celle, G, Dodero, M, Pannacciulli, I, Fresco, G, Mansi, C, Savarino, V & Bogliolo, G 1975, 'Methotrexate effects on enteric mucosa liver and pancreas of normal and bled rats', European Journal of Cancer (1965), vol. 11, no. 5. https://doi.org/10.1016/0014-2964(75)90058-4
Celle, G. ; Dodero, M. ; Pannacciulli, I. ; Fresco, G. ; Mansi, C. ; Savarino, V. ; Bogliolo, G. / Methotrexate effects on enteric mucosa liver and pancreas of normal and bled rats. In: European Journal of Cancer (1965). 1975 ; Vol. 11, No. 5.
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