Il methotrexate nella terapia dell'artrite periferica in corso di rettocolite ulcerosa

Translated title of the contribution: Methotrexate in the treatment of peripheral arthritis in ulcerative colitis

Rosario Peluso, M. Atteno, S. Iervolino, V. Bruner, F. Caso, L. Costa, M. Raimondo, M. Lofrano, F. Manguso, R. Scarpa

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate efficacy of methotrexate treatment in peripheral arthritis of ulcerative colitis. Methods: We studied 18 patients (10/8 M/F; mean age: 38.90 yrs; range: 21-65 yrs), with peripheral arthritis (14 with polyarticular, 4 with oligoarticular subset) associate ulcerative colitis. Methotrexate 20 mg/ week was administered in our patients, who were already receiving mesalazina for inflammatory bowel disease. At baseline, after 3 (T1), 6 (T2) and 12 months (T3) serological parameters (ESR and CRP), functional status (HAQ) and disease activity (VAS, GH, Ritchie articular index) were evaluated. Results: During the therapy a significant improvement was observed in disease activity, functional status and serological parameters since T1. ESR and CRP did not change at T2 and T3. Instead VAS, GH, Ritchie articular index and HAQ had a significant and gradual improvement from T1 to T3. Conclusion: Methotrexate treatment was efficacious in the treatment of peripheral arthritis associate ulcerative colitis. This drug induced improvement in disease activity, functional status and serological parameters after 3 months of therapy.

Translated title of the contributionMethotrexate in the treatment of peripheral arthritis in ulcerative colitis
Original languageItalian
Pages (from-to)15-20
Number of pages6
JournalReumatismo
Volume61
Issue number1
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Rheumatology

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