Methyl bromide myoclonus: An electrophysiological study

A. Uncini, M. Basciani, A. Di Muzio, D. Antonini, M. Onofrj

Research output: Contribution to journalArticlepeer-review


We report a case of myoclonus from overnight exposure to methyl bromide. Myoclonus was either spontaneous or induced by somatosensory stimulation or voluntary movements, multifocal and sometimes generalized. Median SEP showed normal size P14-N20, but giant parietal P25, N33 and frontal P22-N30 waves. Back-averaging showed a biphasic EEG spike of maximal amplitude at the central region contralateral to the corresponding myoclonic jerk recorded from abductor pollicis brevis and preceding it by a short interval consistent with conduction in corticospinal pathway. Long latency reflexes from cutaneous and mixed nerve stimulation were enhanced. The above electrophysiological findings suggest that myoclonus following methyl bromide poisoning belongs to the cortical reflex myoclonus category.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalActa Neurologica Scandinavica
Issue number2
Publication statusPublished - 1990


  • back-averaging
  • giant somatosensory evoked potentials
  • long latency reflex
  • methyl bromide
  • myoclonus

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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