Abstract
Cancer evolution at all stages (including initiation, progression and invasion) is driven by both epigenetic abnormalities and genetic alterations. Epigenetics refer to any structural modification of genomic regions, which lead to modification in gene expression without alterations in DNA sequence. Progressive deregulation of epigenetic process is being increasingly recognized in liver carcinogenesis. This review will provide an overview of DNA methylation, one of the most commonly epigenetic events, which profoundly contributes to liver cancer initiation and progression. Furthermore, the recent advancements in the knowledge of epigenetic reprogramming underlying hepatic cancer stem cells will be highlighted.
| Original language | English |
|---|---|
| Pages (from-to) | 564-571 |
| Number of pages | 8 |
| Journal | Clinics and Research in Hepatology and Gastroenterology |
| Volume | 37 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 2013 |
Fingerprint
ASJC Scopus subject areas
- Gastroenterology
Cite this
Methylation and liver cancer. / Raggi, Chiara; Invernizzi, Pietro.
In: Clinics and Research in Hepatology and Gastroenterology, Vol. 37, No. 6, 12.2013, p. 564-571.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Methylation and liver cancer
AU - Raggi, Chiara
AU - Invernizzi, Pietro
PY - 2013/12
Y1 - 2013/12
N2 - Cancer evolution at all stages (including initiation, progression and invasion) is driven by both epigenetic abnormalities and genetic alterations. Epigenetics refer to any structural modification of genomic regions, which lead to modification in gene expression without alterations in DNA sequence. Progressive deregulation of epigenetic process is being increasingly recognized in liver carcinogenesis. This review will provide an overview of DNA methylation, one of the most commonly epigenetic events, which profoundly contributes to liver cancer initiation and progression. Furthermore, the recent advancements in the knowledge of epigenetic reprogramming underlying hepatic cancer stem cells will be highlighted.
AB - Cancer evolution at all stages (including initiation, progression and invasion) is driven by both epigenetic abnormalities and genetic alterations. Epigenetics refer to any structural modification of genomic regions, which lead to modification in gene expression without alterations in DNA sequence. Progressive deregulation of epigenetic process is being increasingly recognized in liver carcinogenesis. This review will provide an overview of DNA methylation, one of the most commonly epigenetic events, which profoundly contributes to liver cancer initiation and progression. Furthermore, the recent advancements in the knowledge of epigenetic reprogramming underlying hepatic cancer stem cells will be highlighted.
UR - http://www.scopus.com/inward/record.url?scp=84888430321&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84888430321&partnerID=8YFLogxK
U2 - 10.1016/j.clinre.2013.05.009
DO - 10.1016/j.clinre.2013.05.009
M3 - Article
C2 - 23806627
AN - SCOPUS:84888430321
VL - 37
SP - 564
EP - 571
JO - Clinics and Research in Hepatology and Gastroenterology
JF - Clinics and Research in Hepatology and Gastroenterology
SN - 2210-7401
IS - 6
ER -