Methylation-dependent T cell immunity to Mycobacterium tuberculosis heparin-binding hemagglutinin

Stéphane Temmerman, Kevin Pethe, Marcela Parra, Sylvie Alonso, Carine Rouanet, Thames Pickett, Annie Drowart, Anne Sophie Debrie, Giovanni Delogu, Franco D. Menozzi, Christian Sergheraert, Michael J. Brennan, Françoise Mascart, Camille Locht

Research output: Contribution to journalArticlepeer-review

Abstract

Although post-translational modifications of protein antigens may be important componenets of some B cell epitopes, the determinants of T cell immunity are generally nonmodified peptides. Here we show that methylation of the Mycobacterium tuberculosis heparin-binding hemagglutinin (HBHA) by the bacterium is essential for effective T cell immunity to this antigen in infected healthy humans and in mice. Methylated HBHA provides high levels of protection against M. tuberculosis challenge in mice, whereas nonmethylated HBHA does not. Protective immunity induced by methylated HBHA is comparable to that afforded by vaccination with bacille Calmette et Guérin, the only available anti-tuberculosis vaccine. Thus, post-translational modifications of proteins may be crucial for their ability to induce protective T cell-mediated immunity against infectious diseases such as tuberculosis.

Original languageEnglish
Pages (from-to)935-941
Number of pages7
JournalNature Medicine
Volume10
Issue number9
DOIs
Publication statusPublished - Sep 2004

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Fingerprint Dive into the research topics of 'Methylation-dependent T cell immunity to Mycobacterium tuberculosis heparin-binding hemagglutinin'. Together they form a unique fingerprint.

Cite this