Methylation-independent silencing of the p73 gene in neuroblastoma

B. Banelli, I. Casciano, M. Romani

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

p73 is a p53 homolog that, in vitro, inhibits cell growth and induce apoptosis. In some tumors p73 is monoallelically expressed and this raised the possibility that this gene is subjected to imprinting. Silencing of p73 in acute leukemia and in Burkitt's lymphoma occurs in association with the aberrant methylation of the first exon of the gene. We have analysed the methylation pattern of the p73 promoter and of upstream and downstream sequences in neuroblastoma. Our results demonstrate that p73 expression in this tumor is not regulated by methylation. We concluded that it is unlikely that p73 is imprinted in neuroblastoma and that the methylation-dependent silencing of this gene, thus far, is a characteristic of hematologic malignancies.

Original languageEnglish
Pages (from-to)4553-4556
Number of pages4
JournalOncogene
Volume19
Issue number39
Publication statusPublished - Sep 14 2000

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Gene Silencing
Neuroblastoma
Methylation
Burkitt Lymphoma
Hematologic Neoplasms
Genes
Exons
Neoplasms
Leukemia
Apoptosis
Growth

Keywords

  • Chromosome 1
  • Methylation
  • Neuroblastoma
  • P73

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Methylation-independent silencing of the p73 gene in neuroblastoma. / Banelli, B.; Casciano, I.; Romani, M.

In: Oncogene, Vol. 19, No. 39, 14.09.2000, p. 4553-4556.

Research output: Contribution to journalArticle

Banelli, B, Casciano, I & Romani, M 2000, 'Methylation-independent silencing of the p73 gene in neuroblastoma', Oncogene, vol. 19, no. 39, pp. 4553-4556.
Banelli B, Casciano I, Romani M. Methylation-independent silencing of the p73 gene in neuroblastoma. Oncogene. 2000 Sep 14;19(39):4553-4556.
Banelli, B. ; Casciano, I. ; Romani, M. / Methylation-independent silencing of the p73 gene in neuroblastoma. In: Oncogene. 2000 ; Vol. 19, No. 39. pp. 4553-4556.
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