Methylenetetrahydrofolate reductase and angiotensin converting enzyme gene polymorphisms in two genetically and diagnostically distinct cohort of Alzheimer patients

Davide Seripa, Gloria Dal Forno, Maria G. Matera, Carolina Gravina, Maurizio Margaglione, Mark T. Palermo, David R. Wekstein, Piero Antuono, Daron G. Davis, Antonio Daniele, Carlo Masullo, Alessandra Bizzarro, Massimo Gennarelli, Vito M. Fazio

Research output: Contribution to journalArticle

Abstract

The role of methylenetetrahydrofolate reductase (MTHFR) and angiotensin converting enzyme (ACE) gene polymorphisms as risk factors for the occurrence of Alzheimer's disease (AD) is still controversial. In this study, we investigated the common MTHFR C677→T and ACE insertion/deletion (I/D) gene polymorphisms as risk factors for AD in two genetically and diagnostically distinct cohort of Alzheimer's patients. We analyzed a neuropathologically confirmed American cohort of 124 AD patients and 97 elderly controls, and a clinically diagnosed Italian cohort of 126 probable AD cases, 106 elderly controls, and a community-based sample of 1232 subjects aged under 65 years. No difference was found in polymorphism distribution between cases and controls in both study cohorts. We also tested a possible association between the polymorphisms investigated. No interaction was found between the MTHFR and ACE alleles. Moreover, no association was found for the ACE and MTHFR polymorphisms with age at onset, disease duration and MMSE score at observation. Thus, in our study, MTHFR C677→T and ACE I/D polymorphisms do not appear to confer an added risk for AD.

Original languageEnglish
Pages (from-to)933-939
Number of pages7
JournalNeurobiology of Aging
Volume24
Issue number7
DOIs
Publication statusPublished - Nov 2003

Keywords

  • Alzheimer's disease
  • Angiotensin converting enzyme
  • Gene polymorphism
  • Methylenetetrahydrofolate reductase

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

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    Seripa, D., Dal Forno, G., Matera, M. G., Gravina, C., Margaglione, M., Palermo, M. T., Wekstein, D. R., Antuono, P., Davis, D. G., Daniele, A., Masullo, C., Bizzarro, A., Gennarelli, M., & Fazio, V. M. (2003). Methylenetetrahydrofolate reductase and angiotensin converting enzyme gene polymorphisms in two genetically and diagnostically distinct cohort of Alzheimer patients. Neurobiology of Aging, 24(7), 933-939. https://doi.org/10.1016/S0197-4580(03)00040-X