Metronomic chemotherapy for cancer treatment: A decade of clinical studies

Adriana Romiti, M. Christina Cox, Ida Sarcina, Roberta Di Rocco, Chiara D'Antonio, Viola Barucca, Paolo Marchetti

Research output: Contribution to journalArticle

Abstract

Purpose: Over the past few years, more and more new selective molecules directed against specific cellular targets have become available for cancer therapy, leading to impressive improvements. In this evolving scenario, a new way of delivering older cytotoxic drugs has also been developing. Many studies demonstrated that several cytotoxic drugs have antiangiogenic properties if administered frequently and at lower doses compared with standard schedules containing maximal tolerated doses (MTD). Such a new strategy, named metronomic chemotherapy, focuses on a different target: the slowly proliferating tumour endothelial cells. About 10 years ago, metronomic chemotherapy was firstly enunciated and hereafter many clinical experiences were published related to almost any cancer disease. This review analyses available studies dealing with metronomic chemotherapy and its combination with several targeted agents in solid tumours. Methods: A computerized literature search of MEDLINE was performed using the following search terms: metronomic OR "continuous low dose" AND chemotherapy AND cancer OR solid tumours. Results: Satisfactory results have been achieved in diverse tumour types, such as breast and prostate cancer or paediatric sarcomas. Moreover, many studies have reported that metronomic chemotherapy determined minimal toxicity compared to MTD chemotherapy. Overall, published series on metronomic schedules are very heterogeneous often reporting on retrospective data, while only very few studies were randomized trials. These limitations still prevent to draw definitive conclusions in diverse tumour types. Conclusions: Large well-designed studies are eagerly awaited for confirming the promises of metronomic schedules and their combinations with targeted molecules.

Original languageEnglish
Pages (from-to)13-33
Number of pages21
JournalCancer Chemotherapy and Pharmacology
Volume72
Issue number1
DOIs
Publication statusPublished - Jul 2013

Keywords

  • "Continuous low dose" chemotherapy
  • Cancer therapy
  • Metronomic chemotherapy
  • Solid tumours

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pharmacology
  • Pharmacology (medical)
  • Toxicology

Fingerprint Dive into the research topics of 'Metronomic chemotherapy for cancer treatment: A decade of clinical studies'. Together they form a unique fingerprint.

  • Cite this

    Romiti, A., Cox, M. C., Sarcina, I., Di Rocco, R., D'Antonio, C., Barucca, V., & Marchetti, P. (2013). Metronomic chemotherapy for cancer treatment: A decade of clinical studies. Cancer Chemotherapy and Pharmacology, 72(1), 13-33. https://doi.org/10.1007/s00280-013-2125-x