Mevalonate pathway and isoprenoids regulate human bronchial myocyte proliferation

Teresa Viganò, Alicia Hernandez, Alberto Corsini, Agnese Granata, Pierangelo Belloni, Remo Fumagalli, Rodolfo Paoletti, Giancarlo Folco

Research output: Contribution to journalArticle

Abstract

The role of mevalonate and geranylgeraniol in the control of cellular proliferation of cultured human bronchial myocytes was examined by investigating the effect of simvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme in mevalonate synthesis. Simvastatin inhibited the rate of growth of human bronchial smooth muscle cells in a concentration-dependent manner, with an IC50 value of 0.97±0.1 μM. Mevalonate (100 μM), as well as geranylgeraniol (5 μM), at their highest non-toxic concentrations, restored cell proliferation to control levels.

Original languageEnglish
Pages (from-to)201-203
Number of pages3
JournalEuropean Journal of Pharmacology: Molecular Pharmacology
Volume291
Issue number2
DOIs
Publication statusPublished - Oct 15 1995

Keywords

  • Cell proliferation
  • Geranylgeraniol
  • Human bronchial myocyte
  • Mevalonate
  • Simvastatin

ASJC Scopus subject areas

  • Pharmacology

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  • Cite this

    Viganò, T., Hernandez, A., Corsini, A., Granata, A., Belloni, P., Fumagalli, R., Paoletti, R., & Folco, G. (1995). Mevalonate pathway and isoprenoids regulate human bronchial myocyte proliferation. European Journal of Pharmacology: Molecular Pharmacology, 291(2), 201-203. https://doi.org/10.1016/0922-4106(95)90143-4