The role of mevalonate and geranylgeraniol in the control of cellular proliferation of cultured human bronchial myocytes was examined by investigating the effect of simvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme in mevalonate synthesis. Simvastatin inhibited the rate of growth of human bronchial smooth muscle cells in a concentration-dependent manner, with an IC50 value of 0.97±0.1 μM. Mevalonate (100 μM), as well as geranylgeraniol (5 μM), at their highest non-toxic concentrations, restored cell proliferation to control levels.
|Number of pages||3|
|Journal||European Journal of Pharmacology: Molecular Pharmacology|
|Publication status||Published - Oct 15 1995|
- Cell proliferation
- Human bronchial myocyte
ASJC Scopus subject areas