Mevalonate pathway and isoprenoids regulate human bronchial myocyte proliferation

Teresa Viganò, Alicia Hernandez, Alberto Corsini, Agnese Granata, Pierangelo Belloni, Remo Fumagalli, Rodolfo Paoletti, Giancarlo Folco

Research output: Contribution to journalArticlepeer-review

Abstract

The role of mevalonate and geranylgeraniol in the control of cellular proliferation of cultured human bronchial myocytes was examined by investigating the effect of simvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme in mevalonate synthesis. Simvastatin inhibited the rate of growth of human bronchial smooth muscle cells in a concentration-dependent manner, with an IC50 value of 0.97±0.1 μM. Mevalonate (100 μM), as well as geranylgeraniol (5 μM), at their highest non-toxic concentrations, restored cell proliferation to control levels.

Original languageEnglish
Pages (from-to)201-203
Number of pages3
JournalEuropean Journal of Pharmacology: Molecular Pharmacology
Volume291
Issue number2
DOIs
Publication statusPublished - Oct 15 1995

Keywords

  • Cell proliferation
  • Geranylgeraniol
  • Human bronchial myocyte
  • Mevalonate
  • Simvastatin

ASJC Scopus subject areas

  • Pharmacology

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