MFN2-related neuropathies: Clinical features, molecular pathogenesis and therapeutic perspectives

Giulia Stuppia, Federica Rizzo, Giulietta Riboldi, Roberto Del Bo, Monica Nizzardo, Chiara Simone, Giacomo P. Comi, Nereo Bresolin, Stefania Corti

Research output: Contribution to journalArticlepeer-review


Abstract Mitofusin 2 (MFN2) is a GTPase dynamin-like protein of the outer mitochondrial membrane, encoded in the nuclear genome by the MFN2 gene located on the short (p) arm of chromosome 1. MFN2 protein is involved in several intracellular pathways, but is mainly involved in a network that has an essential role in several mitochondrial functions, including fusion, axonal transport, interorganellar communication and mitophagy. Mutations in the gene encoding MFN2 are associated with Charcot-Marie-Tooth disease type 2A (CMT2A), a neurological disorder characterized by a wide clinical phenotype that involves the central and peripheral nervous system. Here, we present the clinical, genetic and neuropathological features of human diseases associated with MFN2 mutations. We also report proposed pathogenic mechanisms through which MFN2 mutations likely contribute to the development of neurodegeneration. MFN2-related disorders may occur more frequently than previously considered, and they may represent a paradigm for the study of the defective mitochondrial dynamics that seem to play a significant role in the molecular and cellular pathogenesis of common neurodegenerative diseases; thus they may also lead to the identification of related therapeutic targets.

Original languageEnglish
Article number13818
Pages (from-to)7-18
Number of pages12
JournalJournal of the Neurological Sciences
Issue number1-2
Publication statusPublished - Sep 15 2015


  • Charcot-Marie-Tooth disease type 2A
  • Clinical and genetic features
  • Mitochondrial network
  • Mitofusin 2
  • Neurodegeneration
  • Pathogenetic mechanisms

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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