MGAT5 and disease severity in progressive multiple sclerosis

Federica Esposito; Jerome Wojcik; Mariaemma Rodegher; Marta Radaelli; Lucia Moiola; Angelo Ghezzi; Ruggero Capra; Paola Brambilla; Melissa Sorosina; Giacomo Giacalone; Vittorio Martinelli; Giancarlo Comi; Hadi Abderrahim; Filippo Martinelli Boneschi

doi:10.1016/j.jneuroim.2010.10.026

MGAT5 and disease severity in progressive multiple sclerosis

Federica Esposito, Jerome Wojcik, Mariaemma Rodegher, Marta Radaelli, Lucia Moiola, Angelo Ghezzi, Ruggero Capra, Paola Brambilla, Melissa Sorosina, Giacomo Giacalone, Vittorio Martinelli, Giancarlo Comi, Hadi Abderrahim, Filippo Martinelli Boneschi

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

MGAT5 was demonstrated to be associated to multiple sclerosis (MS) severity. We evaluated its role in progressive MS. We studied 11 SNPs mapping to MGAT5 in an Italian cohort of primary progressive or progressive-relapsing patients. The rs1257169^G allele is associated with lower disease severity (p-value=0.02). Adding the age of onset as covariate, another SNP, rs539588, is nominally significant. None of the SNPs survived after multiple testing correction. These results, even if suggestive of MGAT5 involvement also in progressive MS severity, require a bigger sample size to confirm and better explore the role of this locus in this rare disease course.

Original language	English
Pages (from-to)	143-147
Number of pages	5
Journal	Journal of Neuroimmunology
Volume	230
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2010.10.026
Publication status	Published - Jan 2011

Keywords

Disease progression
MGAT5
Primary Progressive Multiple Sclerosis
Single nucleotide polymorphism

ASJC Scopus subject areas

Immunology
Clinical Neurology
Immunology and Allergy
Neurology

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10.1016/j.jneuroim.2010.10.026

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MGAT5 and disease severity in progressive multiple sclerosis. / Esposito, Federica; Wojcik, Jerome; Rodegher, Mariaemma; Radaelli, Marta; Moiola, Lucia; Ghezzi, Angelo; Capra, Ruggero; Brambilla, Paola; Sorosina, Melissa; Giacalone, Giacomo; Martinelli, Vittorio ; Comi, Giancarlo; Abderrahim, Hadi; Boneschi, Filippo Martinelli.

In: Journal of Neuroimmunology, Vol. 230, No. 1-2, 01.2011, p. 143-147.

Research output: Contribution to journal › Article › peer-review

Esposito, Federica ; Wojcik, Jerome ; Rodegher, Mariaemma ; Radaelli, Marta ; Moiola, Lucia ; Ghezzi, Angelo ; Capra, Ruggero ; Brambilla, Paola ; Sorosina, Melissa ; Giacalone, Giacomo ; Martinelli, Vittorio ; Comi, Giancarlo ; Abderrahim, Hadi ; Boneschi, Filippo Martinelli. / MGAT5 and disease severity in progressive multiple sclerosis. In: Journal of Neuroimmunology. 2011 ; Vol. 230, No. 1-2. pp. 143-147.

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abstract = "MGAT5 was demonstrated to be associated to multiple sclerosis (MS) severity. We evaluated its role in progressive MS. We studied 11 SNPs mapping to MGAT5 in an Italian cohort of primary progressive or progressive-relapsing patients. The rs1257169G allele is associated with lower disease severity (p-value=0.02). Adding the age of onset as covariate, another SNP, rs539588, is nominally significant. None of the SNPs survived after multiple testing correction. These results, even if suggestive of MGAT5 involvement also in progressive MS severity, require a bigger sample size to confirm and better explore the role of this locus in this rare disease course.",

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AU - Ghezzi, Angelo

AU - Capra, Ruggero

AU - Brambilla, Paola

AU - Sorosina, Melissa

AU - Giacalone, Giacomo

AU - Martinelli, Vittorio

AU - Comi, Giancarlo

AU - Abderrahim, Hadi

AU - Boneschi, Filippo Martinelli

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AB - MGAT5 was demonstrated to be associated to multiple sclerosis (MS) severity. We evaluated its role in progressive MS. We studied 11 SNPs mapping to MGAT5 in an Italian cohort of primary progressive or progressive-relapsing patients. The rs1257169G allele is associated with lower disease severity (p-value=0.02). Adding the age of onset as covariate, another SNP, rs539588, is nominally significant. None of the SNPs survived after multiple testing correction. These results, even if suggestive of MGAT5 involvement also in progressive MS severity, require a bigger sample size to confirm and better explore the role of this locus in this rare disease course.

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MGAT5 and disease severity in progressive multiple sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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