TY - JOUR
T1 - MGAT5 and disease severity in progressive multiple sclerosis
AU - Esposito, Federica
AU - Wojcik, Jerome
AU - Rodegher, Mariaemma
AU - Radaelli, Marta
AU - Moiola, Lucia
AU - Ghezzi, Angelo
AU - Capra, Ruggero
AU - Brambilla, Paola
AU - Sorosina, Melissa
AU - Giacalone, Giacomo
AU - Martinelli, Vittorio
AU - Comi, Giancarlo
AU - Abderrahim, Hadi
AU - Boneschi, Filippo Martinelli
PY - 2011/1
Y1 - 2011/1
N2 - MGAT5 was demonstrated to be associated to multiple sclerosis (MS) severity. We evaluated its role in progressive MS. We studied 11 SNPs mapping to MGAT5 in an Italian cohort of primary progressive or progressive-relapsing patients. The rs1257169G allele is associated with lower disease severity (p-value=0.02). Adding the age of onset as covariate, another SNP, rs539588, is nominally significant. None of the SNPs survived after multiple testing correction. These results, even if suggestive of MGAT5 involvement also in progressive MS severity, require a bigger sample size to confirm and better explore the role of this locus in this rare disease course.
AB - MGAT5 was demonstrated to be associated to multiple sclerosis (MS) severity. We evaluated its role in progressive MS. We studied 11 SNPs mapping to MGAT5 in an Italian cohort of primary progressive or progressive-relapsing patients. The rs1257169G allele is associated with lower disease severity (p-value=0.02). Adding the age of onset as covariate, another SNP, rs539588, is nominally significant. None of the SNPs survived after multiple testing correction. These results, even if suggestive of MGAT5 involvement also in progressive MS severity, require a bigger sample size to confirm and better explore the role of this locus in this rare disease course.
KW - Disease progression
KW - MGAT5
KW - Primary Progressive Multiple Sclerosis
KW - Single nucleotide polymorphism
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U2 - 10.1016/j.jneuroim.2010.10.026
DO - 10.1016/j.jneuroim.2010.10.026
M3 - Article
C2 - 21115203
AN - SCOPUS:78650966090
VL - 230
SP - 143
EP - 147
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -