mGlu1 receptor-induced LTD of NMDA receptor transmission selectively at schaffer collateral-CA1 synapses mediates metaplasticity

Mehdi Bhouri, Paul A. Farrow, Aneeta Motee, Xu Yan, Giuseppe Battaglia, Luisa Di Menna, Barbara Riozzi, Ferdinando Nicoletti, Stephen M. Fitzjohn, Zafar I. Bashir

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Hippocampal CA1 pyramidal neurons receive inputs from entorhinal cortex directly via the temporoammonic (TA) pathway and indirectly via the Schaffer collateral (SC) pathway from CA3. NMDARs at synapses of both pathways are critical for the induction of synaptic plasticity, information processing, and learning and memory. We now demonstrate that, in the rat hippocampus, activity-dependent mGlu1 receptor-mediated LTD (mGlu1-LTD) of NMDAR-mediated transmission (EPSCNMDA) at the SC-CA1 input prevents subsequent LTP of AMPAR-mediated transmission. In contrast, there was no activity-dependent mGlu1-LTD of EPSCNMDA at the TA-CA1 pathway, or effects on subsequent plasticity of AMPAR-mediated transmission. Therefore, the two major pathways delivering information to CA1 pyramidal neurons are subject to very different plasticity rules.

Original languageEnglish
Pages (from-to)12223-12229
Number of pages7
JournalJournal of Neuroscience
Volume34
Issue number36
DOIs
Publication statusPublished - Sep 3 2014

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N-Methyl-D-Aspartate Receptors
Synapses
Hippocampus
Pyramidal Cells
Entorhinal Cortex
Neuronal Plasticity
Critical Pathways
Automatic Data Processing
Learning

Keywords

  • LTD
  • Metaplasticity
  • NMDARs

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

mGlu1 receptor-induced LTD of NMDA receptor transmission selectively at schaffer collateral-CA1 synapses mediates metaplasticity. / Bhouri, Mehdi; Farrow, Paul A.; Motee, Aneeta; Yan, Xu; Battaglia, Giuseppe; Di Menna, Luisa; Riozzi, Barbara; Nicoletti, Ferdinando; Fitzjohn, Stephen M.; Bashir, Zafar I.

In: Journal of Neuroscience, Vol. 34, No. 36, 03.09.2014, p. 12223-12229.

Research output: Contribution to journalArticle

Bhouri, Mehdi ; Farrow, Paul A. ; Motee, Aneeta ; Yan, Xu ; Battaglia, Giuseppe ; Di Menna, Luisa ; Riozzi, Barbara ; Nicoletti, Ferdinando ; Fitzjohn, Stephen M. ; Bashir, Zafar I. / mGlu1 receptor-induced LTD of NMDA receptor transmission selectively at schaffer collateral-CA1 synapses mediates metaplasticity. In: Journal of Neuroscience. 2014 ; Vol. 34, No. 36. pp. 12223-12229.
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AU - Bhouri, Mehdi

AU - Farrow, Paul A.

AU - Motee, Aneeta

AU - Yan, Xu

AU - Battaglia, Giuseppe

AU - Di Menna, Luisa

AU - Riozzi, Barbara

AU - Nicoletti, Ferdinando

AU - Fitzjohn, Stephen M.

AU - Bashir, Zafar I.

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AB - Hippocampal CA1 pyramidal neurons receive inputs from entorhinal cortex directly via the temporoammonic (TA) pathway and indirectly via the Schaffer collateral (SC) pathway from CA3. NMDARs at synapses of both pathways are critical for the induction of synaptic plasticity, information processing, and learning and memory. We now demonstrate that, in the rat hippocampus, activity-dependent mGlu1 receptor-mediated LTD (mGlu1-LTD) of NMDAR-mediated transmission (EPSCNMDA) at the SC-CA1 input prevents subsequent LTP of AMPAR-mediated transmission. In contrast, there was no activity-dependent mGlu1-LTD of EPSCNMDA at the TA-CA1 pathway, or effects on subsequent plasticity of AMPAR-mediated transmission. Therefore, the two major pathways delivering information to CA1 pyramidal neurons are subject to very different plasticity rules.

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