mGlu1 receptor-induced LTD of NMDA receptor transmission selectively at schaffer collateral-CA1 synapses mediates metaplasticity

Mehdi Bhouri; Paul A. Farrow; Aneeta Motee; Xu Yan; Giuseppe Battaglia; Luisa Di Menna; Barbara Riozzi; Ferdinando Nicoletti; Stephen M. Fitzjohn; Zafar I. Bashir

doi:10.1523/JNEUROSCI.0753-14.2014

mGlu1 receptor-induced LTD of NMDA receptor transmission selectively at schaffer collateral-CA1 synapses mediates metaplasticity

Mehdi Bhouri, Paul A. Farrow, Aneeta Motee, Xu Yan, Giuseppe Battaglia, Luisa Di Menna, Barbara Riozzi, Ferdinando Nicoletti, Stephen M. Fitzjohn, Zafar I. Bashir

www.neuromed.it

Research output: Contribution to journal › Article › peer-review

Abstract

Hippocampal CA1 pyramidal neurons receive inputs from entorhinal cortex directly via the temporoammonic (TA) pathway and indirectly via the Schaffer collateral (SC) pathway from CA3. NMDARs at synapses of both pathways are critical for the induction of synaptic plasticity, information processing, and learning and memory. We now demonstrate that, in the rat hippocampus, activity-dependent mGlu1 receptor-mediated LTD (mGlu1-LTD) of NMDAR-mediated transmission (EPSC_NMDA) at the SC-CA1 input prevents subsequent LTP of AMPAR-mediated transmission. In contrast, there was no activity-dependent mGlu1-LTD of EPSC_NMDA at the TA-CA1 pathway, or effects on subsequent plasticity of AMPAR-mediated transmission. Therefore, the two major pathways delivering information to CA1 pyramidal neurons are subject to very different plasticity rules.

Original language	English
Pages (from-to)	12223-12229
Number of pages	7
Journal	Journal of Neuroscience
Volume	34
Issue number	36
DOIs	https://doi.org/10.1523/JNEUROSCI.0753-14.2014
Publication status	Published - Sep 3 2014

Keywords

LTD
Metaplasticity
NMDARs

ASJC Scopus subject areas

Neuroscience(all)

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mGlu1 receptor-induced LTD of NMDA receptor transmission selectively at schaffer collateral-CA1 synapses mediates metaplasticity. / Bhouri, Mehdi; Farrow, Paul A.; Motee, Aneeta; Yan, Xu; Battaglia, Giuseppe ; Di Menna, Luisa; Riozzi, Barbara; Nicoletti, Ferdinando; Fitzjohn, Stephen M.; Bashir, Zafar I.

In: Journal of Neuroscience, Vol. 34, No. 36, 03.09.2014, p. 12223-12229.

Research output: Contribution to journal › Article › peer-review

Bhouri, Mehdi ; Farrow, Paul A. ; Motee, Aneeta ; Yan, Xu ; Battaglia, Giuseppe ; Di Menna, Luisa ; Riozzi, Barbara ; Nicoletti, Ferdinando ; Fitzjohn, Stephen M. ; Bashir, Zafar I. / mGlu1 receptor-induced LTD of NMDA receptor transmission selectively at schaffer collateral-CA1 synapses mediates metaplasticity. In: Journal of Neuroscience. 2014 ; Vol. 34, No. 36. pp. 12223-12229.

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AU - Yan, Xu

AU - Battaglia, Giuseppe

AU - Di Menna, Luisa

AU - Riozzi, Barbara

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AU - Fitzjohn, Stephen M.

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