The studies of age-associated immune remodeling have been concentrated for many years on the adaptive response, particularly considering the relevance of post-pubertal thymus involution that may determine the level of specific immunity. For the past few years, however, the interest has been increasing in innate immunity, based on new knowledge of its integration with specific immune effector mechanisms and its key role in initiating the clonal response of adaptive immunity. This paper will examine the numerical and functional alterations of MHC-unrestricted immunity during ageing, particularly focusing on cytotoxic cells, and the role that alterations of these cells may have in the age-related impairment of adaptive immunity.
ASJC Scopus subject areas
- Clinical Neurology