Mice anesthesia, analgesia, and care, Part II: anesthetic considerations in preclinical imaging studies.

Sara Gargiulo, Adelaide Greco, Matteo Gramanzini, Silvia Esposito, Andrea Affuso, Arturo Brunetti, Giancarlo Vesce

Research output: Contribution to journalArticle

Abstract

Animal experiments are necessary for a better understanding of diseases and for developing new therapeutic strategies. The mouse (Mus musculus) is currently the most popular laboratory animal in biomedical research. Mice imaging procedures are increasingly used in preclinical research because they allow in vivo monitoring and they are readily available for longitudinal and noninvasive studies as well as investigations into the evolution of diseases and the effects of new therapies. New imaging techniques and sophisticated laboratory animal imaging tools are currently producing a large body of evidence about the possible interference of anesthesia with different imaging methods that have the potential to compromise the results of in vivo studies. The purpose of this article is to review the existing literature on molecular imaging studies in mice, to describe the effects of different anesthetic protocols on their outcome, and to report our own experience with such studies.

Original languageEnglish
JournalILAR journal / National Research Council, Institute of Laboratory Animal Resources
Volume53
Issue number1
Publication statusPublished - 2012

ASJC Scopus subject areas

  • Medicine(all)

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