Micro-economics of apoptosis in cancer: NcRNAs modulation of BCL-2 family members

L. Villanova, S. Careccia, R. De Maria, M.E. Fiori

Research output: Contribution to journalArticlepeer-review

Abstract

In the last few years, non-coding RNAs (ncRNAs) have been a hot topic in cancer research. Many ncRNAs were found to regulate the apoptotic process and to play a role in tumor cell resistance to treatment. The apoptotic program is on the frontline as self-defense from cancer onset, and evasion of apoptosis has been classified as one of the hallmarks of cancer responsible for therapy failure. The B-cell lymphoma 2 (BCL-2) family members are key players in the regulation of apoptosis and mediate the activation of the mitochondrial death machinery in response to radiation, chemotherapeutic agents and many targeted therapeutics. The balance between the pro-survival and the pro-apoptotic BCL-2 proteins is strictly controlled by ncRNAs. Here, we highlight the most common mechanisms exerted by microRNAs, long non-coding RNAs and circular RNAs on the main mediators of the intrinsic apoptotic cascade with particular focus on their significance in cancer biology. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Original languageEnglish
JournalInternational Journal of Molecular Sciences
Volume19
Issue number4
DOIs
Publication statusPublished - 2018

Keywords

  • Apoptosis
  • BCL-2 family
  • Cancer
  • Long non-coding RNAs
  • MicroRNAs
  • Therapy resistance
  • microRNA
  • protein bcl 2
  • untranslated RNA
  • animal
  • apoptosis
  • genetics
  • human
  • neoplasm
  • physiology
  • Animals
  • Humans
  • Neoplasms
  • Proto-Oncogene Proteins c-bcl-2
  • RNA, Untranslated

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