Microalbuminuria in hypertensive nondiabetic patients with ST elevation myocardial infarction

Chiara Lazzeri, Serafina Valente, Marco Chiostri, Claudio Picariello, Gian F. Gensini

Research output: Contribution to journalArticle

Abstract

Objectives: Previous investigations on microalbuminuria in acute myocardial infarction have been performed in heterogeneous populations of hypetensive/nonhypertensive, diabetic/nondiabetic patients, submitted to either thrombolysis or mechanical revascularization or not revascularized. Therefore, the aim of our investigation was to assess, in 242 consecutive hypertensive patients with ST elevation myocardial infarction without previously known diabetes, all submitted to mechanical revascularization, whether microalbuminuria, in the early phase, has a prognostic role for in-hospital mortality or complications (acute pulmonary edema and arrhythmias). Methods: The study population was divided into two groups according to microalbuminuria excretion: group A (microalbuminuria within the normal range); group B (microalbuminuria above the normal range). Results: The incidence of microalbuminuria was 52.1% (126/242). No significant difference was detectable in the incidence of in-hospital mortality and complications between the two groups. Patients with microalbuminuria exhibit a larger infarct size as indicated by higher values of troponin I. Microalbuminuria was associated with higher values of glucose and a higher prevalence of insulin resistance. Conclusion: In ST elevation myocardial infarction hypertensive patients without previously known diabetes, all submitted to mechanical revascularization, microalbuminuria is a common finding but it does not yield prognostic information about in-hospital mortality or complications. Interestingly it was associated with acute glucose dysmetabolism (as inferred by hyperglycemia and the prevalence of insulin resistance), thus suggesting that it can be considered part of the acute metabolic response to the acute coronary event.

Original languageEnglish
Pages (from-to)748-753
Number of pages6
JournalJournal of Cardiovascular Medicine
Volume11
Issue number10
DOIs
Publication statusPublished - Oct 2010

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Hospital Mortality
Insulin Resistance
Reference Values
Mechanical Thrombolysis
Glucose
Troponin I
Incidence
Pulmonary Edema
Hyperglycemia
Population
Cardiac Arrhythmias
Myocardial Infarction
ST Elevation Myocardial Infarction

Keywords

  • Hyperglycemia
  • hypertension
  • insulin resistance
  • microalbuminuria
  • nondiabetic
  • percutaneous coronary intervention
  • STEMI

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Microalbuminuria in hypertensive nondiabetic patients with ST elevation myocardial infarction. / Lazzeri, Chiara; Valente, Serafina; Chiostri, Marco; Picariello, Claudio; Gensini, Gian F.

In: Journal of Cardiovascular Medicine, Vol. 11, No. 10, 10.2010, p. 748-753.

Research output: Contribution to journalArticle

Lazzeri, Chiara ; Valente, Serafina ; Chiostri, Marco ; Picariello, Claudio ; Gensini, Gian F. / Microalbuminuria in hypertensive nondiabetic patients with ST elevation myocardial infarction. In: Journal of Cardiovascular Medicine. 2010 ; Vol. 11, No. 10. pp. 748-753.
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N2 - Objectives: Previous investigations on microalbuminuria in acute myocardial infarction have been performed in heterogeneous populations of hypetensive/nonhypertensive, diabetic/nondiabetic patients, submitted to either thrombolysis or mechanical revascularization or not revascularized. Therefore, the aim of our investigation was to assess, in 242 consecutive hypertensive patients with ST elevation myocardial infarction without previously known diabetes, all submitted to mechanical revascularization, whether microalbuminuria, in the early phase, has a prognostic role for in-hospital mortality or complications (acute pulmonary edema and arrhythmias). Methods: The study population was divided into two groups according to microalbuminuria excretion: group A (microalbuminuria within the normal range); group B (microalbuminuria above the normal range). Results: The incidence of microalbuminuria was 52.1% (126/242). No significant difference was detectable in the incidence of in-hospital mortality and complications between the two groups. Patients with microalbuminuria exhibit a larger infarct size as indicated by higher values of troponin I. Microalbuminuria was associated with higher values of glucose and a higher prevalence of insulin resistance. Conclusion: In ST elevation myocardial infarction hypertensive patients without previously known diabetes, all submitted to mechanical revascularization, microalbuminuria is a common finding but it does not yield prognostic information about in-hospital mortality or complications. Interestingly it was associated with acute glucose dysmetabolism (as inferred by hyperglycemia and the prevalence of insulin resistance), thus suggesting that it can be considered part of the acute metabolic response to the acute coronary event.

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